TCR signal strength defines distinct mechanisms of T cell ...

TCR signal strength defines distinct mechanisms of T cell ... - PubMed

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific ...

TCR signal strength determines T cell differentiation and function in tumors, with high-signal-strength interactions resulting in ...

TCR signal strength defines distinct mechanisms of T cell ...

To investigate the impact of TCR signal strength on TST cell differentiation and dysfunction during tumor development, we generated a cancer mouse model with a ...

TCR signal strength defines distinct mechanisms of T cell ... - BVS

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST ...

(PDF) TCR signal strength defines distinct mechanisms of T cell ...

We developed a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor antigens with varying TCR signal strength. High-signal- ...

TCR signal strength defines distinct mechanisms of T cell ... - OUCI

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST ...

Regulation of T Helper Cell Fate by TCR Signal Strength - Frontiers

In this review, we summarize the signaling cascades regulated by the strength of TCR stimulation. Various mechanisms in which TCR signal strength controls T ...

T cells transduce T-cell receptor signal strength by generating ...

The molecular mechanisms by which TCR signal strength is transduced to downstream signaling networks remains ill-defined. Using computational modeling, ...

Andrea Schietinger: Publications | Sloan Kettering Institute

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. Journal of Experimental Medicine 2022 Feb 7;219(2):e20201966 ...

Antigen and checkpoint receptor engagement recalibrates T cell ...

Our findings reveal that anti-PD1 immunotherapy leads to an increased TCR signal strength. We defined a strong TCR signal metric of five genes ...

Signal strength regulates antigen-mediated T-cell deceleration by ...

This switch required TCR binding to pMHC but was independent of intracellular TCR signals. Our results suggest that the action of distinct mechanisms tailors ...

T cell receptor (TCR) signaling in health and disease - Nature

Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T ...

TCR signal strength controls the differentiation of CD4+ effector and ...

In contrast, T follicular helper cell (Tfh) specification has been associated, in separate studies, with high-affinity TCRs or TCRs with long ...

JExpMed on X: "TCR signal strength defines distinct mechanisms of ...

TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion, say @MojdehShakiba, Andrea Schietinger ...

TCR Signaling in T Cell Memory - Frontiers

Furthermore, TCR signal strength regulates the input of cytokine signaling, including pro-inflammatory cytokines. These highlight how tailoring antigenic ...

T cell receptor signaling strength establishes the chemotactic ...

Here, using an IFNγ-YFP reporter system to identify CD8+ T cells executing antigen-dependent effector functions, we define the transcriptional ...

Dual receptor T cells mediate effective antitumor immune responses ...

Phenotype and single-cell gene expression analyses identified dual TCR are predominant during the effective antitumor response, demonstrating selectively ...

Defining how T cells measure the strength of T cell receptor signals

TCR signal strength regulated the phosphorylation of AKT which in turn controls AKT substrate specificity so that different TCR signal strengths engage ...

TCR signal strength drives distinct transcriptional and epigenetic...

... publication: TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion | T cell receptor (TCR) signal strength is a key ...

T cell receptor signaling for γδT cell development

T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell ...