TGF|β signaling promotes eosinophil activation in inflammatory ...

TGF-β signaling promotes eosinophil activation in inflammatory ...

This study delineates a distinct pattern of eosinophil activation within inflammatory responses, highlighting the pivotal role of TGF-β signaling in regulating ...

(PDF) TGF-β signaling promotes eosinophil activation in ...

This study delineates a distinct pattern of eosinophil activation within inflammatory responses, highlighting the pivotal role of TGF-β signaling in regulating ...

RNA Seq profiling reveals a novel expression pattern of TGF-β ...

As TGF-β is an important cytokine for eosinophil function and survival, and pulmonary inflammation and fibrosis, our results represent a significant step toward ...

TGF-β production by eosinophils drives the expansion of ...

Brief-Communication. TGF-β production by eosinophils drives the expansion of peripherally induced neuropilin− RORγt+ regulatory T-cells during ...

TGF-β signaling promotes eosinophil activation in inflammatory ...

This study delineates a distinct pattern of eosinophil activation within inflammatory responses, highlighting the pivotal role of TGF-β signaling in regulating ...

Eosinophils mitigate intestinal fibrosis while promoting inflammation ...

In other disease areas, IL-5 inhibition (e.g. by benralizumab, mepolizumab or reslizumab) decreased eosinophil counts and overall type 2 immune ...

TGF-β signaling pathway promoted Eos activation. A Differential...

Our findings provided preliminary evidence supporting that eosinophil activation is dependent on the TGF-β-Smads pathway (Fig. 2D). To reinforce this ...

Transforming growth factor β and severe asthma: A perfect storm

Inhibiting TGF-ß1 signaling specifically in T-cell subsets has led to enhanced airway inflammation, hypersensitivity and increased Th2 cytokine production hence ...

In Vivo Allergen-Activated Eosinophils Promote Collagen I and ...

TGF-β1 is secreted by fibroblasts, endothelial cells, airway epithelial cells, vascular, and ASM cells. However, migrated inflammatory cells, such as ...

Eosinophils enhance WNT-5a and TGF-β 1 genes expression in ...

Eosinophils enhance Wnt-5a, TGF-β 1 , fibronectin, and collagen gene expression in ASMC and promote proliferation of these cells in asthma.

Role of Transforming Growth Factor–β in Airway Remodeling in ...

This profibrotic cytokine is produced by a number of cells, including macrophages, epithelial cells, fibroblasts, and eosinophils. High ...

IL-5 antagonism reverses priming and activation of eosinophils in ...

It also enhances the pro-fibrotic roles of eosinophils in airway remodeling via transforming growth factor-β pathway. These findings provide a ...

The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor ...

Eosinophils were also shown to restrict melanoma growth upon IL-33 treatment through the recruitment and activation of cytotoxic T cells and ...

IL-5-Induced Hypereosinophilia Suppresses the Antigen-Induced ...

IL-5 treatment increased the production of TGF-β1 in the spleen, and we demonstrated that the main cellular source of TGF-β1 production was eosinophils, using ...

Transforming growth factor‐beta1 in inflammatory airway disease: a ...

Eosinophils are a hallmark of asthma and link inflammation to remodeling; studies demonstrated that eosinophils were the main source of TGF-β1 ...

Transforming Growth Factor-β Signaling in Immunity and Cancer

Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor emergence. ... activation nor inflammatory disease in ...

Cellular and molecular basis for the regulation of inflammation by ...

TGF-β inhibits macrophage activation, such as induction of inducible nitric-oxide synthase (iNOS) and matrix metalloproteinase (MMP)-12 via the Smad3 pathway ( ...

TGF-β signaling promotes eosinophil activation in inflammatory ...

In this study, we investigate the local activation of pulmonary and colon eosinophils within the inflammatory microenvironment. Leveraging ...

Frontiers | Eosinophil Cytokines, Chemokines, and Growth Factors

Growth factors have an important role in inflammatory conditions, and those derived from eosinophils are likely to promote an inflammatory phenotype. Among ...

TGF‐β: An Important Mediator of Allergic Disease and a Molecule ...

TGF-β-induced Ras signaling promotes the epithelial-mesenchymal transition (EMT) [45]. Moreover, TGF-β activates the PI3K-Akt signaling pathway.