TNF|α blockade induces IL|10 expression in human CD4 T cells

TNF-α blockade induces IL-10 expression in human CD4+ T cells

IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells

IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi) drugs induce ...

TNF Blockade Maintains an IL-10 + Phenotype in Human Effector ...

CD4+ and CD8+ effector T cell subpopulations can display regulatory potential characterized by expression of the prototypically ...

[PDF] TNF-α blockade induces IL-10 expression in human CD4+ T ...

Time course experiments in whole peripheral blood mononuclear cell (PBMC) cultures show that TNF blockade maintained, rather than increased, IL-10+ cell ...

Identification of a transcription factor network regulating anti-TNF ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells . Nat Commun. 2014. ,. 5. ,. 3199 . doi:10.1038/ncomms4199 · Google Scholar.

TNF-α blockade induces IL-10 expression in human CD4+ T cells ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells. Hayley G. Evans, Urmas Roostalu, Gina J. Walter, Nicola J. Gullick, Klaus S. Frederiksen, Ceri ...

The dichotomous outcomes of TNFα signaling in CD4+ T cells

Distinct membrane expression ... Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction ... TNF downmodulates the function of ...

(PDF) TNF-α blockade induces IL-10 expression in human CD4+ T ...

PDF | IL-17+ CD4+ T (Th17) cells contribute to the pathogenesis of several human inflammatory diseases. Here we demonstrate that TNF inhibitor (TNFi).

Anti‐TNF treatment negatively regulates human CD4+ T‐cell ...

To evaluate the effect of ADA treatment on IL-10 induction in pro-inflammatory populations of CD4+ T cells, we performed mass cytometry (CyTOF) ...

Molecular and functional heterogeneity of IL-10-producing CD4 + T ...

Human IL-10-producing CD4+ T cells are heterogeneous. ... Over-expression ... Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T ...

IKZF3/Aiolos Is Associated with but Not Sufficient for the Expression ...

TNF-α blockade maintains IL10 transcription in CD4+ T cells. We ... TNF-α blockade induces IL-10 expression in human CD4+ T cells. Nat ...

IL-10 signaling in CD4+ T cells is critical for the pathogenesis of ...

Blocking IL-10 signaling in T cells rendered mice, especially female mice, highly susceptible to collagen-induced arthritis. T-cell activation ...

TNF-alpha blockade induces IL-10 expression in human CD4+T cells

TNF-alpha blockade induces IL-10 expression in human CD4+T cells. Hayley G. Evans, Urmas Roostalu, Gina J. Walter, Nicola J. Gullick, Klaus S. Frederiksen ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells

TNF-α blockade induces IL-10 expression in human CD4+ T cells. https://doi.org/10.1038/ncomms4199 · Повний текст. Видання: Nature Communications, 2014, № 1.

TNF-a blockade maintains the expression of IL-10 in CD4 + T cells

After 3 d, the cells were supplemented with fresh 10% FCS RPMI 1640 and 20 U/ml recombinant human IL-2 and rested from stimulation for 3 d. These cells were ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells ...

TNF-α blockade induces IL-10 expression in human CD4+ T cells. Hayley G. Evans, Urmas Roostalu, Gina J. Walter, Nicola J. Gullick, Klaus S. Frederiksen, Ceri ...

TNF plays a crucial role in inflammation by signaling via T cell TNFR2

IL-6 alone induced little ROR-γt expression (Fig. ... CD4+ T cells cultured under TNF-Th17 conditions expressed ... T cells in human ...

IL-10 production by CD4+ effector T cells: a mechanism for self ...

... IL-21 to induce IL-10 expression in CD4+ T lymphocytes. ... expression of IL-10 in human T cells. Conclusions ... Toll pathway-dependent blockade of CD4+CD25+ T ...

The multifaceted nature of IL-10: regulation, role in immunological ...

... to prevent autoimmune inflammatory process in the central nervous system (43, 195). Induction of a homogeneous population of IL-10-producing CD4 T cells by ...

In Vitro Generation of Interleukin 10–producing Regulatory CD4 + T ...

We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vit.