Targeted drug treatment leads tumor cells to imitate viral infection

Reporting in Science, researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery ...

Virus-inspired Strategies for Cancer Therapy - PMC - NCBI

As viruses are inherently immunogenic and naturally optimized delivery vehicles, repurposing viruses for drug delivery, tumor antigen presentation, or selective ...

Oncolytic Virus Enables the Immune System to Attack Tumors

Researchers have modified a cancer-infecting virus so that it blocks the immune-suppressing protein TGF-beta and regulatory T cells (Tregs), helping T cells ...

Broad Institute of MIT and Harvard's Post - LinkedIn

Targeted drug treatment leads tumor cells to imitate viral infection. broadinstitute.org · 191 ...

Virus-mimicking drug helps immune system target cunning cancer ...

The research opens up the possibility of using drugs that simulate viruses to overcome immunotherapy resistance in melanoma.

A research team searches for every gene that helps tumors evade ...

Efforts to probe the entire genome of cancer cells in animals have led to potential new drugs — now in early-stage clinical trials — that ...

Oncolytic viruses: a new class of immunotherapy drugs - PMC

Most oncolytic viruses directly kill host tumour cells. This activity is influenced by the efficiency of cell receptor targeting, viral replication and host ...

Neoantigens: promising targets for cancer therapy - Nature

Notably, immunogenic peptides derived from dysregulated PTMs in cancer cells constitute an unexplored class of tumor-specific neoantigens that ...

Researchers mimic viral infection in colon cancer stem cells

Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a ...

Targeted recruitment of immune effector cells for rapid ... - PNAS

With the ability of influenza virus to infect and mutate in animals before transmission to humans, efforts to integrate an immunotherapy and chemotherapy into a ...

Monoclonal antibody drugs for cancer: How they work - Mayo Clinic

Some immune system cells depend on antibodies to locate the target of an attack. Cancer cells that are coated in monoclonal antibodies may be more easily ...

Immunotherapy: Oncolytic Virus Therapy - Cancer Research Institute

Oncolytic virus therapy uses modified viruses that infect and destroy tumor cells. Learn more about how it's helping to advance cancer treatment.

Viruses for Tumor Therapy - ScienceDirect

Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer.

Therapeutic targets and biomarkers of tumor immunotherapy - Nature

In the context of tumors, it was found that ICB targeting PD-1 usually leads to the expansion and recruitment of existing antitumor T cells, ...

Joining Forces: The Combined Application of Therapeutic Viruses ...

The early 2000s saw the development of OVs targeting cancer cells, with recent progress highlighting herpes virus efficacy in colorectal cancer therapy.

Medical Xpress on X: "Targeted drug treatment leads ##tumorCells ...

Targeted drug treatment leads ##tumorCells to imitate viral infection, researchers discover @broadinstitute @sciencemagazine ...

Using Oncolytic Viruses to Treat Cancer - NCI

“The oncolytic virus kills tumor cells and causes the release of danger signals, which help to generate an immune response,” explained Dr.

Virus-mimicking drug helps immune system target cunning cancer ...

The team first attempted to overcome defective interferon signalling by using adoptive T cell therapy, a type of immunotherapy that involves ...

Virus‐mimetic systems for cancer diagnosis and therapy - Gao - 2021

(2017) used the penetrating peptide (pepM or pepR) derived from the virus capsid proteins to deliver siRNA to leukemia cells and consequently ...

Improving cancer immunotherapy by rationally combining oncolytic ...

Reovirus and vaccinia virus naturally possess the ability to specially target cancer cells driven by the activated Ras pathway. Reovirus ...