- Targeted protein degradation using intracellular antibodies and its ...🔍
- Targeted protein degradation🔍
- Targeted Intracellular Delivery of Antibodies🔍
- Degrading proteins with intracellular antibodies🔍
- Targeted protein degradation in lysosome utilizing naturally ...🔍
- Targeted Protein Degradation 🔍
- Targeted protein degradation through site|specific antibody ...🔍
- Intracellular Antibodies for Drug Discovery and as Drugs of the Future🔍
Targeted protein degradation using intracellular antibodies and its ...
Targeted protein degradation using intracellular antibodies and its ...
This review will explore the mechanisms by which therapeutic antibodies engage and eliminate intracellularly aggregated proteins.
Targeted protein degradation: mechanisms, strategies and application
The ASGPR-based LYTAC molecule is made by the fusion of antibodies ... degrade extracellular and membrane proteins by harnessing the endosome- ...
Targeted Intracellular Delivery of Antibodies: The State of the Art
One possible way to engage in the therapy of intracellular “undruggable” protein targets is the use of antibodies. Antibodies could be raised against different ...
Targeted Intracellular Delivery of Antibodies: The State of the Art
Intracellular proteins that act at immune checkpoints are other possible targets (Klepsch et al., 2018) for which inhibition by antibodies might ...
Degrading proteins with intracellular antibodies | Nature Methods
Researchers develop a genetic method for degradation of GFP protein fusions in cells and living flies. Markus Affolter from the University ...
Targeted protein degradation in lysosome utilizing naturally ...
Novel antibodies have been created for targeted degradation of extracellular and membrane proteins in the lysosome. The mechanism of degradation ...
Targeted Protein Degradation (TPD) for Immunotherapy
Table 1 gives a comprehensive overview of ICIs approved by the FDA, emphasizing anti-PD-1, anti-CTLA-4, and anti-PD-L1 antibodies, their ...
Targeted protein degradation through site-specific antibody ...
Herein we have developed a novel site-specific antibody conjugation approach to generate antibody mannose 6-phosphate (M6P) conjugates. The method uses a high ...
Intracellular Antibodies for Drug Discovery and as Drugs of the Future
Protein degradation was suggested as another route to control cellular phenotype by invoking proteosome degradation of targets in yeast [24].
The Translational Potential for Target Validation and Therapy Using ...
... antibody and the cellular degradation machinery, resulting in selective protein knock-down. ... the cell surface by intracellular antibodies targeted to the ...
Applying Antibodies Inside Cells: Principles and Recent Advances ...
... with intracellular targets at the protein ... Targeting endogenous proteins for degradation through the affinity-directed protein missile system.
A programmable targeted protein-degradation platform for versatile ...
... target proteins by utilizing different readily available, off-the ... Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
A cell-based screening method using an intracellular antibody for ...
A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2.
Targeted protein degradation directly engaging lysosomes or ...
Targeted degradation of intracellular proteins and organelles through the autophagy machinery ... the antibody was accomplished by using ...
Recent advancements in targeted protein knockdown technologies ...
Targeted intracellular delivery of antibodies: the state of the art. ... Cell-free Trim-Away reveals the mechanism of antibody-mediated protein degradation by ...
Targeted protein degradation by Trim-Away using cell resealing ...
We also confirmed that the delivered antibody could successfully bind to the intracellular target by resealing the anti-GFP antibody in HeLa ...
Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted ...
Here, we describe a strategy for selective protein degradation in a specific cell type. We report the design and synthesis of a trastuzumab-PROTAC conjugate (Ab ...
A Targeted Protein Degradation Cell-Based Screening for ...
We identified one intracellular antibody (intrabody) that shows selective targeting of endogenous RHOB-GTP medi- ated by interactions between ...
Opportunities and challenges of protein-based targeted protein ...
20. However, small molecule PROTACs and molecular glue degraders rely on the intracellular protein degradation machinery, which limits their use ...
Protocol to select conformation-specific intracellular antibodies for ...
Targeted protein degradation (TPD) strategy harnesses the ubiquitin-proteasome system (UPS) to degrade a protein of interest (POI) by bringing ...