Targeting Adenosine Receptors in Neurological Diseases

Targeting Adenosine Receptors in Neurological Diseases - PubMed

Adenosine plays a significant role in neurotransmission process by controlling the blood pressure, while adenosine triphosphate (ATP) acts as a ...

In this review, we have selected neurological disorders (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and ...

Why target brain adenosine receptors? A historical perspective

Adenosine A 2A receptors are selectively localized to the basal ganglia. A 2A receptors provide a distinct target for PD therapeutics.

Targeting Adenosine Receptors: A Potential Pharmacological ...

Activation of A2AARs by endogenous adenosine or exogenous agonists results in antinociception in case of inflammatory pain. While, A2AARs ...

Adenosine receptors and brain diseases: Neuroprotection and ...

In spite of this current mechanistic uncertainty, it seems evident that targeting adenosine receptors might indeed constitute a novel strategy to control the ...

Targeting Adenosine Signaling in Parkinson's Disease - Frontiers

Adenosine affects dopaminergic signaling through receptor heteromer formations and shared intracellular pathways. Adenosine is a neuromodulator that acts ...

Adenosine Receptors in Neuropsychiatric Disorders - MDPI

Adenosine exerts an important role in the modulation of central nervous system (CNS) activity. Through the interaction with four G-protein coupled receptor ...

Emerging roles of dysregulated adenosine homeostasis in brain ...

A1R and A2AR are the major adenosine receptor subtypes in the brain and can be found in both neurons and glia. In many pathophysiological ...

Targeting adenosine A2A receptors in Parkinson's disease

The adenosine A 2A receptor has emerged as an attractive non-dopaminergic target in the pursuit of improved therapy for Parkinson's disease (PD).

Adenosine A2A Receptors as Biomarkers of Brain Diseases - Frontiers

Adenosine A2A Receptors in Brain Diseases ... Upon acute brain injury, probably best exemplified by an ischemic brain stroke, concurrent pharmacological and ...

Adenosine receptor signalling in Alzheimer's disease

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in the pathogenesis of dementia. Targeting ...

Focusing on Adenosine Receptors as a Potential Targeted Therapy ...

Initially, ARs were grouped into A1 and A2 receptors based on their effects in inhibiting and stimulating cyclic AMP (cAMP) in the brain [44]. Currently, the ...

The adenosine A2A receptor is a therapeutic target in neurological ...

Introduction. Following approval of antagonists in Parkinson's disease therapy, the A2A adenosine receptor (A2AR) is gaining interest as a target to combat a ...

[PDF] A2A Adenosine Receptor: A Possible Therapeutic Target for ...

A2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer's Disease by Regulating NLRP3 Inflammasome Activity? · S. Merighi, Manuela Nigro, +5 authors

Adenosine receptors and neurological disease - AIR Unimi

Adenosine receptors modulate neuronal and synaptic function in a range of ways that may make them relevant to the occurrence, development and treatment of brain ...

Adenosine receptor targeting in health and disease

Expert opinion: Selective ligands of A1, A2A, A2B and A3 adenosine receptors are likely to find applications in the treatment of pain, ischemic ...

Adenosine Receptors in Neurological Therapy Advances - Editverse

Alzheimer's Disease. In Alzheimer's, A1 and A2A adenosine receptors are out of balance, leading to memory loss and damage. Therapies targeting these can slow ...

A2A Adenosine Receptor - IRIS

Interestingly, a growing body of evidence suggests a role of NLRP3 inflammasome as a target to treat neurodegenerative diseases. It ...

Adenosine receptors and brain diseases: Neuroprotection and ...

... targeting adenosine receptors might indeed constitute a novel strategy to control the demise of different neurological and psychiatric disorders. This ...

Brain Adenosine Receptors as Targets for Therapeutic Intervention ...

The A1 receptor has long been known to mediate neuroprotection, mostly by blockade of Ca2+ influx, which results in inhibition of glutamate ...