Targeting SOX18 Transcription Factor Activity by Small|Molecule ...

Targeting SOX18 Transcription Factor Activity by Small-Molecule ...

The transcription factor SOX18 has been shown to play a crucial role in lung cancer progression and metastasis.

Article Small-Molecule Inhibitors of the SOX18 Transcription Factor

None of the SOX18 inhibitors displayed any COX-1 or COX-2 inhibitory activity up to a concentration of 200 μM (Figures S1A and S1B). Off-Target Profiling. We ...

(PDF) Targeting SOX18 Transcription Factor Activity by Small ...

The SOX18 protein has been suggested to be a significant diagnostic and prognostic marker in various types of cancer. SRY-related HMG-box 18 ( ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

... targeting TF activity. This study is the first to report that the developmental SOX TFs are amenable to pharmacological modulation by a small molecule via ...

Pharmacological targeting of the transcription factor SOX18 delays ...

A novel molecular strategy to block transcription factor activity using small molecule interference of multiple protein-protein interactions ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

of small molecules with a selectivity for a selected subset of protein-protein interaction may provide an alternative strat- egy for targeting TF activity.

Small-Molecule Inhibitors of the SOX18 Transcription Factor

However, developing pharmacological molecules to target TF activity is very challenging since they are shielded by the nuclear membrane, and their three- ...

Transcription Factor SOX18 Promotes Clear Cell Renal Cell ...

Importantly, Overman and colleagues demonstrated that targeting SOX18 with a small-molecule inhibitor was an effective approach to treat breast cancer in mice ( ...

R-propranolol is a small molecule inhibitor of the SOX18 ... - eLife

... SOX18 transcription factor activity breaks open ... SOX18 transcription factor as a molecular target in the context of vascular diseases.

Targeting SOX18 Transcription Factor Activity by Small-Molecule ...

The transcription factor SOX18 has been shown to play a crucial role in lung cancer progression and metastasis. In this study, we investigated the effect of ...

Homodimerization regulates an endothelial specific signature of the ...

A.A.. Pharmacological targeting of the transcription factor SOX18 ... et al. Small-Molecule inhibitors of the SOX18 transcription factor .

Functional domain analysis of SOX18 transcription factor using a ...

... molecular target in various pathophysiological conditions. We hereby ... proteins (in this case homodimerization) required to activate gene trans-activation.

SOX18 transcription factor interactome: Protein‐Protein interaction a ...

This work opens up a new molecular strategy to target transcription factor activity and reposition this class of protein as viable drug target.

dominant-negative SOX18 mutant disrupts multiple regulatory layers ...

... transcription factor activity ... A.A.. et al. . Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.

Pharmacological targeting of the transcription factor SOX18 delays ...

Our studies validate an interactome-based molecular strategy to interfere with transcription factor activity, for the development of novel ...

Pharmacological targeting of the transcription factor SOX18 delays ...

The observed Sm4-induced phenotype supports the conclusion that Sox7 activity is partially affected in presence of the small compound. However, the treated ...

Pharmacological targeting of the transcription factor SOX18 delays ...

... validate an interactome-based molecular strategy to interfere with transcription factor activity, for the development of novel disease therapeutics.

Pharmacological targeting of the transcription factor SOX18 delays ...

... molecular strategy to interfere with transcription factor activity, for the development of novel disease therapeutics.

SOX18 exerts tumor-suppressive functions in papillary thyroid ...

Targeting SOX18 Transcription Factor Activity by Small-Molecule Inhibitor Sm4 in Non-Small Lung Cancer Cell Lines. 2023, International ...

Oncogenic Herpesvirus Engages Endothelial Transcription Factors ...

These results provide a proof of principle that targeting SOX18 could represent a novel molecular strategy for Kaposi sarcoma treatment. SOX18 binds to the KSHV ...