Targeting TRP channels

Advances in TRP channel drug discovery: from target validation to ...

In this Review, we discuss recent findings in TRP channel structural biology that can affect both drug development and clinical indications.

Targeting TRP channels for pain relief: A review of current evidence ...

Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception.

Targeting TRP channels: recent advances in structure, ligand ...

In this short review, we summarize recent progresses toward understanding the structural basis of TRP channel function, as well as potential ligand binding ...

TRP (transient receptor potential) ion channel family - Nature

... targeting TRP channels in potential clinical applications ... As is true for all TRP channels, TRPV channels are tetrameric and each ...

Targeting nociceptive transient receptor potential channels to treat ...

The mammalian TRP superfamily has been divided into six subfamilies based on sequence homology: canonical (TRPC1 to TRPC7), vanilloid (TRPV1 to TRPV6), ...

Targeting TRP channels for pain relief: A review of current evidence ...

The TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain.

Transient receptor potential (TRP) channels as drug targets for ...

These implications identify TRP channels as promising drug targets for the management of a number of gastrointestinal pathologies.

TRP channels: Role in neurodegenerative diseases and therapeutic ...

Recent studies have highlighted the potential of TRP channels as therapeutic targets for NDs, as their increased activity has been observed in several ...

Cannabinoid Ligands Targeting TRP Channels - Frontiers

In this review article, we aim to provide an overview and classification of the cannabinoid ligands that have been reported to modulate TRP channels and their ...

A Potential Therapeutic Target for Nociceptive Pain - Sage Journals

The transient receptor potential (TRP) superfamily of ion channels in humans comprises voltage-gated, non-selective cation channels ...

Targeting TRP Channels for Pain, Itch and Neurogenic Inflammation

This article belongs to the Special Issue Targeting TRP Channels for Pain, Itch and Inflammation Relief

TRP Channels as Potential Drug Targets - Annual Reviews

The transient receptor potential (TRP) superfamily of channels comprises a diverse group of cation channels. Four TRP channel subunits coassemble to form ...

Targeting TRP Channels - Valuable Alternatives to Combat Pain ...

Transient receptor potential (TRP) channels are a family of functionally diverse and widely expressed cation channels involved in a variety ...

Targeting TRP Channels For Novel Migraine Therapeutics

It is now clear that blocking the actions of CGRP, released from dural afferent terminals and central endings in the brainstem, is effective in ...

TRP Channels: Their Function and Potentiality as Drug Targets

The transient receptor potential (TRP) proteins are a family of ion channels that act as cellular sensors as well as signal integrators.

Transient Receptor Potential channels (TRP) | Ion channels

Most TRP channels are regulated by phosphoinostides such as PtIns(4,5)P2 although the effects reported are often complex, occasionally contradictory, and likely ...

Full article: TRP channels as emerging targets for pain therapeutics

Among other thermo-TRPs (including TRPV2 – 4, Ankyrin type TRP 1 (TRPA1) and melastatin type TRP 8 (TRPM8)), TRPA1 and TRPM8 are emerging as promising novel ...

TRP Channels: Recent Development in Translational Research and ...

The transient receptor potential family encodes integral membrane proteins that function as ion channels. TRP channels are divided into seven subfamilies based ...

Targeting TRP channels – valuable alternatives to combat pain ...

T2DM: Type II diabetes mellitus, the most common type of diabetes mellitus, characterized by insulin resistance. TRP channel: Transient Receptor Potential ...

Targeting TRP channels for chronic cough: from bench to bedside

This review will cover the current understanding of the role of the TRP family of ion channels in the activation of airway sensory nerves and cough.