Targeting Tumor Microenvironment by Small|Molecule Inhibitors

Targeting Tumor Microenvironment by Small-Molecule Inhibitors

In this review, we briefly summarize the recent advances of small-molecule inhibitors that target TME for the tumor treatment.

Targeting Tumor Microenvironment by Small-Molecule Inhibitors

The tumor microenvironment (TME) is a hypoxic, acidic, and immune/inflammatory cell-enriched milieu that plays crucial roles in tumor development, growth, ...

Advantages of targeting the tumor immune microenvironment over ...

Consequently, the toxicity of ICP-targeting drugs differs from that of conventional chemotherapies, targeted small molecule inhibitors, or even ...

Small molecules in targeted cancer therapy: advances, challenges ...

Primary resistance to FLT3 inhibitors involves insensitive FLT3 mutations, expression of FGF2 or CYP3A4 in the bone marrow microenvironment, ...

Therapeutic Targeting of the Tumor Microenvironment

... cancer cell survival (43). Neutralizing antibodies and small-molecule inhibitors directed against CSF1R have been used to either deplete ...

Small molecule inhibitors as adjuvants in cancer immunotherapy

Effective infiltration of immune cells into the tumor microenvironment is essential for mounting a robust anti-tumor immune response. Small molecule inhibitors ...

Therapeutic targeting of PD-1/PD-L1 blockade by novel small ...

... small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment ... 19 However, to date, effective small-molecule inhibitors targeting ...

Tumor microenvironment: barrier or opportunity towards effective ...

Recently, several small molecular inhibitors have been developed to target acidic tumor microenvironment, and Zhong et al. provides a detailed ...

Targeting Tumor Microenvironment by Small-Molecule Inhibitors

Semantic Scholar extracted view of "Targeting Tumor Microenvironment by Small-Molecule Inhibitors" by Shangwei Zhong et al.

Targeting the tumor microenvironment: Potential strategy for cancer ...

One of them is a topoisomerase 1 inhibitor, which has been licensed by the FDA and is used as a second-line therapy for small cell lung and ovarian cancer [77].

Targeting the Tumor Microenvironment: From Understanding ...

SU6668, a small-molecule kinase inhibitor for PDGFR, VEGFR, and FGFR, has currently completed phase I clinical trials in patients with advanced solid tumors.

Therapeutic targeting of the tumor microenvironment: Cancer Cell

57. Lam, L.T. ∙ Davis, R.E. ∙ Pierce, J. ... Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups ...

Targeting tumour microenvironment by tyrosine kinase inhibitor

Understanding on the mode of action of tyrosine kinases had led to discovery of many small molecule inhibitors proved to be effective for the ...

Targets of tumor microenvironment for potential drug development

In non-small cell lung cancer (NSCLC) mouse models, the inhibition of mono-adenosine 5ʹ-diphosphate (ADP)-ribosyltransferase 1 (ART1) led to a ...

Inhibition of tumor–microenvironment interaction and tumor invasion ...

... tumor and tumor stromal cells has been established as critical for breast cancer metastasis. Small molecule inhibitors that target the ...

Targeting the Tumor Microenvironment: A Close Up of ... - Frontiers

Accordingly, treatment with AMD3100 (plerixafor, Mozobil), a small-molecule inhibitor of CXCR4, promotes an enhanced intratumoral immune B and T cell responses ...

Targeting Tumor Microenvironment for Cancer Therapy - MDPI

When embedded in the basement membrane of the small caliber vessels, pericytes secrete endothelial cells growth factors, MMP inhibitors and ECM molecules, ...

Targeting pulmonary tumor microenvironment with CXCR4 ...

Our work suggests that the CXCR4-inhibiting nanocomplex decreases tumor fibrosis, facilitates T cell infiltration and relieves immunosuppression.

A Comprehensive Exploration of Agents Targeting Tumor ...

... small-molecule inhibitors targeting ... S. Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma ...

Targeting the tumor microenvironment: removing obstruction to ...

The balance between a large number of different immune cells, immune factors, and signaling molecules determines the outcome of the antitumor immune response.