Targeting autophagy regulation in NLRP3 inflammasome|mediated ...

Targeting autophagy regulation in NLRP3 inflammasome-mediated ...

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Targeting autophagy regulation in NLRP3 inflammasome-mediated ...

Clin Immunol. 2022 Aug 6;244:109093. doi: 10.1016/j.clim.2022.109093 Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID

The Role of the Effects of Autophagy on NLRP3 Inflammasome in ...

With the continuous progress of research, targeting autophagy and NLRP3 ... Mechanism and regulation of NLRP3 inflammasome activation. Trends ...

IRGM/Irgm1 increases autophagy to inhibit activation of NLRP3 ...

Autophagy has been shown to target the degradation of the NLRP3 inflammasome ... Inflammasomes: mechanism of assembly, regulation and signalling.

Targeting microglial autophagic degradation of the NLRP3 ...

NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer's disease (AD).

Interplay Between NLRP3 Inflammasome and Autophagy - Frontiers

Imatinib-Sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis. Cell Host Microbe. (2011) 10 ...

Targeting autophagy regulation in NLRP3 inflammasome-mediated ...

Request PDF | Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19 | Coronavirus disease 2019 ...

The regulation of NLRP3 inflammasome activation by CCDC50 ...

In the meantime, the autophagy cargo receptor CCDC50 is induced and then CCDC50 targets K63-polyubiqutinated NLRP3 for autophagic ...

Regulation of inflammasomes by autophagy

Autophagy eliminates damaged phagosomes to prevent aberrant activation of the NLRP3 inflammasome. IL-1β. Autophagosome. Degradation. Targeting. Engulfment. ASC.

Inflammasome and Autophagy Regulation: A Two-way Street

Inflammasome-forming NLRP3 has also been shown to negatively regulate autophagy through downregulation ... mediated precision autophagy targets ...

Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy ...

FoxG1 suppressed NLRP3-mediated neuroinflammation, which was strongly linked to autophagy regulated by AMPK/mTOR.

Pharmacological targets at the lysosomal autophagy–NLRP3 ...

The lysosomal autophagy–inflammasome axis is a crucial immune regulation pathway linking inflammasome activation and autophagy, allowing their mutual influence.

Interaction among inflammasome, autophagy and non-coding RNAs

Therefore, as the core of the inflammatory response, NLRP3 inflammasome studies may indicate new targets for the treatment of various ...

An update on the regulatory mechanisms of NLRP3 inflammasome ...

... autophagy have been reported to play roles in the regulation of the NLRP3 inflammasome. ... targeting the myofibroblast NLRP3 inflammasome ...

Regulation of inflammasomes by autophagy

Fig 5 Autophagy suppresses NLRP3 inflammasome activation. Stimulatory ... Activation of autophagy by inflammatory signals limits IL-1β production by targeting ...

Autophagy in Atherosclerotic Plaque Cells: Targeting NLRP3 ... - MDPI

Inflammasome regulation by selective autophagy is ripe for study. There has been considerable research on the negative regulation of the inflammasome by ...

Alternative autophagy dampens UVB-induced NLRP3 ...

Therefore, it is important to identify the regulatory mechanisms that limit UV-induced NLRP3 inflammasome activation in order to block excessive inflammatory ...

Targeting autophagy regulation in NLRP3 inflammasome-mediated ...

Targeting autophagy regulation in NLRP3 inflammasome-mediated lung inflammation in COVID-19. https://doi.org/10.1016/j.clim.2022.109093 ·. Journal: Clinical ...

Pharmacological targets at the lysosomal autophagy-NLRP3 ...

Current understanding of NLRP3 inflammasome activation and regulation incriminates this pathway in the induction and maintenance of metabolic inflammation [14, ...

Interplay Between NLRP3 Inflammasome and Autophagy

The authors describe the complex pathways controlling the NLRP3 inflammasome activation and regulation and how it is being targeted to treat inflammatory ...