Targets of tumor microenvironment for potential drug development

The TAM receptor family, comprising Tyro3, Axl, and MerTK, has emerged as a promising target in cancer therapy. ... A previous study highlighted ...

Tumor microenvironment as a therapeutic target in cancer - PMC

TAMs prevented cytotoxic CD8+ T-cells from reaching the tumors and led to unresponsiveness to anti-PD1 immunotherapy. 2.3.2. Developing drugs targeting TAMs.

The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of nontumoral cells or components, and molecules they produce ...

Tumor microenvironment signaling and therapeutics in cancer ...

Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and ...

The updated landscape of tumor microenvironment and drug ...

TME is shaped and trained by cancer cells to assist the development of cancer hallmarks, respond to intrinsic or extrinsic stress, stimulation ...

Targeting the tumor microenvironment: Potential strategy for cancer ...

Consequently, TAMs are being recognized as a promising target for immunotherapy [11]. Local endothelial cells in TME proliferate rapidly to generate vascular ...

Therapeutic targets in tumor microenvironment - EurekAlert!

The review mainly focuses on potential therapeutic targets modulating these three TME components, including targets modulating tumor immune ...

Targets of tumor microenvironment for potential drug development

The frequent and continuous interplay between tumor cells and the TME strongly affects tumor development, disease progression, metastasis, and responses to ...

A Broader Spectrum of Cancer Targets - National Cancer Institute

A variety of tumor-extrinsic factors also contribute to tumorigenesis, including changes in the tumor microenvironment (TME), alterations to the ...

Tumor microenvironment complexity and therapeutic implications at ...

In order to develop a reliable tool for personalized cancer therapy and drug development, it is essential to preserve the key characteristics of ...

Therapeutic targets and biomarkers of tumor immunotherapy - Nature

Immune cells with cytotoxic potential, including T cells, NK cells and macrophages, recognize and eliminate infected or damaged cells under ...

Therapeutic targeting of the tumor microenvironment: Cancer Cell

The supporting players in the tumor microenvironment include stromal fibroblasts, infiltrating immune cells, the blood and lymphatic vascular networks, and the ...

Targeting Tumor Microenvironment by Small-Molecule Inhibitors

Therefore, targeting TME would be an efficient way for the treatment of cancer. Indeed, many strategies have been developed to target the TME. As small ...

The tumor microenvironment: a key player in multidrug resistance in ...

In the TME, interactions between cancer cells and non-malignant cells often modify the TME and facilitate drug resistance. Therefore, ...

Tumor microenvironment: barrier or opportunity towards effective ...

Recent studies have shown that these specialized TME microenvironments and niches have potential to act as target of cancer therapy through ...

Targeting Tumor Microenvironment for Cancer Therapy - MDPI

The development of effective anti-cancer therapies has been challenged by the overall complexity of tumors [1,2,3]. The tumor heterogeneity is exacerbated ...

The Tumor Microenvironment: A Druggable Target for Metastatic ...

This sounds like a difficult question to answer but is rather simple: a desirable target for the treatment of cancer should be expressed in the ...

Current Advance of Therapeutic Agents in Clinical Trials Potentially ...

Emerging evidence suggested that tumor plasticity played critical roles in the emergence of drug resistance and the promotion of tumor growth, invasion and ...

An expanded universe of cancer targets - Cell Press

for cancer target identification and drug development, with stra- tegies either exploiting the immunogenicity of tumor cells, spur- ring the ...

Highlighted STAT3 as a potential drug target for cancer therapy

Recently, the impact of the tumor microenvironment and tumor-induced immune suppression on tumor progression, has been subjected to intense ...