Telomere shortening as a hallmark of stem cell senescence

Telomere shortening as a hallmark of stem cell senescence - NCBI

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation.

Telomere shortening as a hallmark of stem cell senescence - Fathi

This review focuses on prevalent knowledge about the mechanisms of stem cell senescence by telomere shortening and the molecular mechanism details involved in ...

Telomere shortening as a hallmark of stem cell senescence - PubMed

Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through ...

Telomere shortening as a hallmark of stem cell senescence - Fathi

Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through multi-lineage ...

Telomere dysfunction in ageing and age-related diseases - Nature

As replicative cellular senescence is caused by telomere shortening below a critical length ... Telomerase deficiency causes alveolar stem cell ...

(PDF) Telomere shortening as a hallmark of stem cell senescence

PDF | Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through ...

Telomere Shortening as Biological Hallmark of Cellular Senescence ...

Telomere Shortening as Biological Hallmark of Cellular Senescence and Longevity-An Update, Sara Zahid, Fatima Zahid, Faisal Gulzar, Qurban Ali, Ayesha Zahid ...

Telomere shortening is a hallmark of genetic cardiomyopathies | PNAS

... stem cells (hiPSCs) also exhibit significant telomere shortening relative to healthy controls. ... cell division, a marker of aging. CMs ...

Telomere Shortening - an overview | ScienceDirect Topics

Telomere shortening is a hallmark of aging and stress-induced senescence [122]. Telomere length critically affects cell senescence and organism life span.

Telomeres, stem cells, senescence, and cancer - JCI

Therefore, telomere shortening and p53 activation modulate two potent anticancer mechanisms: senescence and apoptosis. While the molecular ...

Telomere shortening induces aging-associated phenotypes in ...

Telomere shortening is a well-established hallmark of cellular aging ... Telomere shortening in neural stem cells disrupts neuronal ...

Telomere Length as a Marker of Biological Age - Frontiers

Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common ...

Telomeres: history, health, and hallmarks of aging - Cell Press

∙ Cayuela, M.L. ∙ Blasco, M.A.. Effects of telomerase and telomere length on epidermal stem cell behavior. Science. 2005; 309:1253-1256.

Review Telomeres: history, health, and hallmarks of aging

Genomic instability, another hallmark of aging, can lead to stem cell ... Effects of telomerase and telomere length on epidermal stem cell ...

[PDF] Telomere length, stem cells and aging. | Semantic Scholar

The current evidence linking telomere shortening to aging and stem cell dysfunction is reviewed to suggest that telomerase activity and telomeres length can ...

Implications for Cellular Senescence and Age-related Diseases

Telomeres play a role in innate immunity after virus infection. Telomere attrition (or telomere shortening) is another hallmark of aging, which ...

Telomeres and Telomerase in the Control of Stem Cells - MDPI

Aging of the regional stem cells and associated telomere shortening are ... Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2015 ...

Mesenchymal Stem Cell Senescence and Rejuvenation - Frontiers

Telomere shortening is believed to be a hallmark of MSC senescence, limiting long-term MSC division that is essential for tissue renewal. For this reason, ...

Telomere shortening as a hallmark of stem cell senescence | CoLab

Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through multi-lineage ...

Markers of cellular senescence. Telomere shortening as ... - Aging-US

... shorter than in cells of non- or low rate proliferative tissues [29]. Despite telomerase activity, the same trend is observed in stem cells. As cells ...