Telomeres and cell senescence

Telomeres and Cell Senescence - Size Matters Not - PMC - NCBI

Telomeres shorten as a result of cellular replication, leading to a permanent cell cycle arrest, also known as replicative senescence.

Telomere dysfunction in ageing and age-related diseases - Nature

Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated ...

Telomeres and cell senescence (video) | Khan Academy

In many mammals somatic cells telomeres tend to get shorter with each division. When they get short enough it seems that the cells will either ...

The role of telomeres and telomerase in the senescence of ...

Telomeres, known as the cell's “biological clock”, are a recognized marker of cell aging [27]. Shortening with each replication division, they determine the ...

Roles of Telomere Biology in Cell Senescence, Replicative and ...

In this review, we summarize the current understandings of telomere regulation of cell replicative and chronological ageing in the pioneer model system ...

Cell Process: What role do the telomeres play in senescence?

Telomeres function as a cellular clock, methods to slow their degradation may prolong tissue health and function by limiting cellular senescence.

Telomeres and cell senescence | Cells | MCAT | Khan Academy

Visit us (http://www.khanacademy.org/science/healthcare-and-medicine) for health and medicine content or ...

Telomeres are favoured targets of a persistent DNA damage ...

Introduction. Cellular senescence is defined as the irreversible loss of division potential in somatic cells and is marked by a number of ...

Implications for Cellular Senescence and Age-related Diseases

Since telomere attrition is a sign of cellular senescence, telomeres are considered as a “life clock” by scientists [20]. The maintenance of ...

Markers of cellular senescence. Telomere shortening as ... - Aging-US

Telomere shortening is a rather elegant frequently used biomarker. Validity of telomere shortening as a marker for cellular senescence is based on theoretical ...

The role of telomeres and telomerase in the senescence of ...

In turn, the senescence of postmitotic cells depends not on the length of telomeres, but their functionality. Dysfunctional telomeres are responsible for ...

Telomeres and senescence: The history, the experiment, the future

Figure 1 The telomere hypothesis of cell senescence and immortalization proposes that: (1) Telomeres are maintained in the germline because of the presence of ...

Telomeres, cellular senescence, and aging: past and future

This review paper delves into the intricate and multifaceted relationship between cellular senescence, the influence of telomeres in this process,

Senescence and immortalization: role of telomeres and telomerase

Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells.

Role of Telomerase in Cell Senescence and Oncogenesis

In this article, we review the role of telomeres and telomerase in senescence and tumor progression, and we discuss the potential use of telomerase in ...

Telomeres and senescence: The history, the experiment, the future

Telomere length has been proposed to signal entry into cellular senescence. Expression of the human telomerase subunit, hTERT, in primary cells now shows that ...

Length doesn't matter—telomere damage triggers cellular ...

Telomere shortening induces cellular senescence in proliferative cells. Yet, it is presently unclear how it is triggered in post‐mitotic ...

Are Telomeres the Key to Aging and Cancer - Learn Genetics (Utah)

Telomeres, which protect our genetic data, make it possible for cells to divide, and hold some secrets to how we age and get cancer.

DNA damage in telomeres and mitochondria during cellular ...

Abstract. Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a.

Telomeric aging: mitotic clock or stress indicator? - Frontiers

Cellular senescence (a state of irreversible cell cycle arrest) occurring in response to a telomere shortening may be regulated by immune surveillance. In this ...