Telomeres are favoured targets of a persistent DNA damage ...

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process.

Abstract. Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process. Telomere shortening ...

Telomeres are favoured targets of a persistent DNA damage ...

Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process. Telomere shortening has ...

(PDF) Telomeres are favored targets of a persistent DNA damage ...

Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible loss of division ...

Telomere dysfunction in ageing and age-related diseases - Nature

In non-proliferating, post-mitotic tissues, telomere dysfunction can be driven by irreparable DNA damage within telomeres. In both cases, the ...

Telomeres and Cell Senescence - Size Matters Not - PMC - NCBI

Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that ...

Telomeres are favoured targets of a persistent DNA damage ...

Endogenous or exogenous DNA damage is constantly generated, and the fraction that occurs at telomeres, which is less efficiently repaired, thus accumulates and ...

Irreparable telomeric DNA damage and persistent DDR signalling ...

When telomeres become critically short, they are sensed as damaged DNA, which triggers a DDR-initiated cellular senescence [8, 9, 10]. Despite ...

Targeted DNA damage at individual telomeres disrupts their integrity ...

Telomeric DNA damage shortens the average length of telomeres and leads to cell senescence in HeLa cells and cell death in HeLa, U2OS and IMR90 ...

Therapeutic potential of targeting telomeric proteins and DNA repair ...

Unprotected telomeres lead to persistent DDR causing cell cycle inhibition, growth arrest, and apoptosis. Cancer cells rely on DDR to protect themselves from ...

Telomeres: beacons of autocrine and paracrine DNA damage ...

Although shortening is an important contributor to telomere dysfunction-induced senescence, a number of recent reports indicate that a persistent DDR can also ...

Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres ...

Accumulation of telomeric 8-oxoG in chronically exposed OGG1-deficient cells triggers replication stress, as evidenced by mitotic DNA synthesis at telomeres.

Telomeres are favoured targets of - H1 Connect

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Hewitt G et al. Nature ...

Telomeres are favoured targets of a persistent DNA ... - Altmetric

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Overview of attention for article ...

Molecular Aspects of Senescence and Organismal Ageing—DNA ...

Telomeres became shorter with age, which correlated with the formation of persistent DDR foci. Impossible to repair persistent DDR foci can cause the cell to go ...

Length doesn't matter—telomere damage triggers cellular ...

Cellular senescence in cardiac myocytes is trigged by persistent DNA damage at telomeres. ... favoured targets of a persistent DNA damage response ...

A DNA damage checkpoint response in telomere-initiated senescence

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence · Biology, Medicine. Nature Communications · 2012.

Slower rates of accumulation of DNA damage in leukocytes ...

An obvious answer is that higher rates of telomere shortening will be associated to faster accumulation of critically short/dysfunctional telomeres, which are ...

The Telomere/Telomerase System in Chronic Inflammatory ... - MDPI

In other words, it seems that telomeric DNA is more sensitive to damage irrespectively of telomere length or telomerase activity. If telomeres become damaged, ...

Telomeric DNA breaks in human induced pluripotent stem cells ...

In dividing cells, telomere DNA shortens with each round of replication (Olovnikov, 1971; Watson, 1972), until telomeres lose sufficient TTAGGG repeats to ...