The Biological Roles of XBP1 Isoforms in Pathophysiology

The Biological Roles of XBP1 Isoforms in Pathophysiology - PubMed

X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced isoform (XBP1-u), ...

The Biological Roles of XBP1 Isoforms in Pathophysiology - MDPI

X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced isoform (XBP1-u), which, ...

The Biological Roles of XBP1 Isoforms in Pathophysiology

X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced isoform (XBP1-u), which, ...

The Biological Roles of XBP1 Isoforms in Pathophysiology

Recent research on the biological functions of both X BP1-u and XBP1-s, as well as their relation to diseases, are summarized.

The Biological Roles of XBP1 Isoforms in Pathophysiology

Abstract and Figures. X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced ...

Spliced or Unspliced, That Is the Question: The Biological Roles of ...

Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology. https://doi.org/10.3390/ijms23052746 ·. Journal ...

Spliced or Unspliced, That Is the Question: The Biological Roles of ...

X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced isoform (XBP1-u), which, ...

Spliced or Unspliced, That Is the Question: The Biological Roles of ...

Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology. X-box binding protein 1 (XBP1) is a member of the ...

Emerging Roles for XBP1, a sUPeR Transcription Factor - PMC

This section highlights and addresses recent reports on the relevance and importance of the IRE1α–XBP1 pathway in multiple pathophysiological conditions such as ...

XBP1 - an overview | ScienceDirect Topics

The multiple functions of XBP1s are required for differentiation of immune cells including CD8+ T cells and B cells, the proper function of α and β pancreatic ...

Biological functions of XBP1-s. - ResearchGate

X-box binding protein 1 (XBP1) is a member of the CREB/ATF basic region leucine zipper family transcribed as the unspliced isoform (XBP1-u), which, ...

XBP1 - an overview | ScienceDirect Topics

Activated IRE1α splices the XBP1 mRNA and generates a functionally active isoform of XBP1 (XBP1s). XBP1s is a transcription factor that regulates the expression ...

XBP1 impacts lung adenocarcinoma progression by promoting ...

Background: The activation of X-box binding protein 1 (XBP1) plays an essential role in the unfolded protein response (UPR) of the endoplasmic ...

A New Link in the Chain: Unspliced XBP1 in Wnt Signaling and ...

Role of XBP1u Versus XBP1s in Metabolic Disease and Its Vascular Manifestations · Dominant Role of XBP1u Versus XBP1s Isoforms in Regulating ...

[PDF] Roles of XBP1s in Transcriptional Regulation of Target Genes ...

110 Citations · Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology · IRE1/XBP1 and endoplasmic reticulum ...

XBP1 - X-box-binding protein 1 - Homo sapiens (Human) - UniProt

Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR).

XBP1 - Wikipedia

The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular ...

The unfolded protein response transcription factor XBP1s ...

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.

Constitutive expression of spliced X-box binding protein 1 inhibits ...

Thereby, XBP1S plays an important role in promoting cell survival and adaptive response to ER stress. In addition, XBP1S is essential for the normal development ...

Unravel the molecular mechanism of XBP1 in regulating the biology ...

Active XBP1 with transactivation domain functions as a transcription factor to regulate the expression of downstream target genes, including many oncogenic ...