The Biology of YAP/TAZ

The biology of YAP/TAZ: hippo signaling and beyond - PubMed

The transcriptional regulators YAP and TAZ are the focus of intense interest given their remarkable biological properties in development, tissue homeostasis ...

The Biology of YAP/TAZ: Hippo Signaling and Beyond

YAP and TAZ are the focus of intense interest given their remarkable biological properties in development, tissue homeostasis and cancer.

YAP/TAZ upstream signals and downstream responses - Nature

Cell behaviour is strongly influenced by physical, mechanical contacts between cells and their extracellular matrix.

The biology of YAP/TAZ: hippo signaling and beyond

The transcriptional regulators YAP and TAZ are the focus of intense interest given their remarkable biological properties in development, tissue homeostasis ...

The biology of YAP in programmed cell death - PMC

YAP and its paralog transcriptional coactivator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which ...

Mechanobiology of YAP and TAZ in physiology and disease - Nature

The transcription factors YAP and TAZ have recently emerged as being conserved transducers of mechanical signals into cells and mediators of ...

YAP/TAZ functions and their regulation at a glance

YAP/TAZ have since become of wide interest in many fields, ranging from developmental to cancer biology, from mechanobiology to stem cells and ...

Role of YAP/TAZ in Cell Lineage Fate Determination and ... - Frontiers

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological ...

YAP/TAZ in Bone and Cartilage Biology - Frontiers

This review provides an overview of YAP/TAZ regulation and function, notably providing new insights into the role of YAP/TAZ in bone biology.

YAP/TAZ at the Roots of Cancer - Cell Press

YAP and TAZ are highly related transcriptional regulators pervasively activated in human malignancies. Recent work indicates that, remarkably, YAP/TAZ are ...

Review The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

YAP/TAZ induction of ARHGAP18 causes increased cytoskeletal tension [57], while YAP induced activation, in a cell-type-dependent manner, of either ARHGAP28 or ...

The biology of YAP/TAZ: hippo signaling and beyond. - Europe PMC

YAP/TAZ are well known for being the effectors of the Hippo signaling cascade, and mouse mutants in Hippo pathway components display remarkable phenotypes of ...

The biology of YAP/TAZ: hippo signaling and beyond.

YAP/TAZ appear at the centerpiece of a signaling nexus by which cells take control of their behavior according to their own shape, spatial location and ...

The Biology of YAP/TAZ: Hippo Signaling and Beyond

Cytoplasmic localization. TEADs. YAP. TAZ. Nucleus. FIGURE 2. A model of the Hippo pathway in mammalian cells. See text for details. THE BIOLOGY OF YAP/TAZ.

The Hippo Pathway, YAP/TAZ, and the Plasma Membrane - Cell Press

Caveolae are composed of caveolin complexes, distinct cavin complexes, EHD, and pacsin proteins. Caveolae regulate YAP/TAZ in a context- and cell-type-dependent ...

Review YAP/TAZ at the Roots of Cancer - ScienceDirect.com

YAP/TAZ are indeed orthologs of Drosophila Yorkie (Huang et al., 2005), and several of the biological traits now assigned to YAP/TAZ were in ...

YAP and TAZ regulate cell volume - Rockefeller University Press

Instead, we find that YAP/TAZ directly impacts the cell division volume, and YAP is involved in regulating intracellular cytoplasmic pressure. Based on the idea ...

The Emerging Role of YAP/TAZ in Tumor Immunity - AACR Journals

Changes in the biological activity of immune cells including development, proliferation, differentiation, and functionality influence tumor progression. The ...

The Hippo pathway effector proteins YAP and TAZ have both distinct ...

The Hippo pathway plays an important role in regulating tissue homeostasis, and its effectors, the transcriptional co-activators Yes-associated protein ...

The role of YAP/TAZ activity in cancer metabolic reprogramming

Subsequently, PFK1-TEAD1-YAP/TAZ forms a complex in the nucleus, which is observed to promote the malignant biological behavior of breast cancer ...