The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 ...

Use of diagnostic codes for primary open-angle glaucoma polygenic risk score construction in electronic health record-linked biobanks.

We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts.

The clinical utility of a glaucoma polygenic risk score in four ... - IOVS

In this prospective cohort study, we evaluate the utility of a polygenetic risk score (PRS) for identification of high-risk subgroups in 4 European-ancestry ...

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 ...

Purpose: We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts. Design: ...

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 ...

Conclusions: Incorporating a PRS into a POAG predictive model improves identification concordance from 0.75 up to 0.82, supporting its potential for guiding ...

The clinical utility of a glaucoma polygenic risk score in four ...

A genetic risk score for the intraocular pressure-independent component of primary open angle glaucoma is associated with 26 different retinal micro-vascular ...

The Clinical Usefulness of a Glaucoma Polygenic Risk Score in 4 ...

Biochemistry, Genetics and Molecular Biology · Polygenic Score 100% · Genotyping 11% · Single-Nucleotide Polymorphism 11% · High Risk Population 11% · Genetic Risk ...

Polygenic Risk Scores Driving Clinical Change in Glaucoma

The high heritability of glaucoma makes it an ideal substrate for genetic risk prediction, with the bulk of risk being polygenic in nature. Here ...

Polygenic Risk Score Improves Prediction of Primary Open Angle ...

Glaucoma is the leading cause of irreversible blindness worldwide with primary open angle glaucoma (POAG) accounting for nearly 69% of global prevalence. Early ...

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of ...

Prior work has similarly demonstrated the potential benefits of combining PRS with clinical or lifestyle risk factors for improving risk ...

Polygenic Risk Scores Driving Clinical Change in Glaucoma

Glaucoma represents an ideal case scenario for the clinical utility of PRSs given that its genetic heritability is very high (134), it has a ...

Polygenic Risk Score Identifies Individuals at Higher Risk of POAG

A polygenic risk score (PRS) was able to identify individuals who had the highest risk of primary open-angle glaucoma (POAG) in a study aimed at finding the ...

Polygenic risk score-based phenome-wide association for glaucoma ...

Polygenic risk scores (PRS) are widely used to synthesize disease-associated single-nucleotide polymorphisms (SNPs) into a single score and ...

Polygenic Risk Scores for Glaucoma Onset in the Ocular ...

Polygenic risk score (PRS) may provide a clinically useful measure of aggregate genetic burden and improve patient risk stratification.

Attitudes Towards Polygenic Risk Testing in Individuals with Glaucoma

Recently, polygenic risk scores (PRSs) have shown promise in stratifying individual risk and prognostication for primary open-angle glaucoma (POAG) to reduce ...

Polygenic Risk Scores for Glaucoma Onset in the Ocular ...

... Polygenic risk scores (PRS) for glaucoma have shown effective stratification of disease risk and severity in recent years. [1][2] [3] [4] . PRS combine ...

Polygenic Risk Scores for POAG in Populations of African Descent

The odds ratios (log scale) of risk for primary open-angle glaucoma from logistic regression by quintile for each of 8 study groups are ...

Development and evaluation of patient-centred polygenic risk score ...

This informed the development of a draft glaucoma screening PRS report for a hypothetical high risk individual from the general population. We ...

Using GWAS and Polygenic risk scores for Glaucoma Risk ... - IOVS

This lecture will review recent POAG GWAS and the clinical features of PRS derived from large multi-ethnic GWAS as well as the proposed clinical utility of PRS.

Selection, optimization and validation of ten chronic disease ...

... risk scores for ten diseases to diverse populations in a clinical ... Responsible use of polygenic risk scores in the clinic: potential benefits, ...