The Different Mechanisms of Cancer Drug Resistance

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

The drug resistance can be occurred by different mechanisms, including multi-drug resistance, cell death inhibiting (apoptosis suppression), altering in the ...

Unveiling the mechanisms and challenges of cancer drug resistance

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and ...

The Different Mechanisms of Cancer Drug Resistance: A Brief Review

Anticancer drugs resistance is a complex process that arises from altering in the drug targets. Advances in the DNA microarray, ...

Molecular chess? Hallmarks of anti-cancer drug resistance

Many mechanisms may contribute to this resistance including reduced drug accumulation and/or increased efflux, site specific mutations affecting ...

Multidrug Resistance in Cancer: Understanding Molecular ...

Drug resistance can occur due to the activation of both intrinsic (pre-existing) or acquired (induced by drugs) mechanisms, and both types of factors play ...

Drug Resistance in Cancer - an overview | ScienceDirect Topics

This has uncovered a number of different mechanisms through which resistance can arise including drug efflux, drug inactivation, drug target alteration, cell ...

Cancer Drug Resistance | CancerQuest

... drug resistance by the cancer ... cancer drugs work by a variety of mechanisms. How is it that cancer cells can become resistant to these different drugs?

Molecular Mechanisms of Cancer Drug Resistance - MDPI

These mechanisms include: upregulation of pro-survival, anti-apoptotic and epithelial-to-mesenchymal transition (EMT)-inducing pathways; ...

Anticancer drug resistance: An update and perspective - ScienceDirect

Multiple studies revealed that cancer drug resistance is based upon a plethora of distinct mechanisms. Drug resistance mutations can occur in the same protein ...

A view on drug resistance in cancer | Nature

The tumour microenvironment—the surrounding space composed of immune cells, stroma and vasculature—may mediate resistance by several mechanisms, ...

Mechanisms of Multidrug Resistance in Cancer Chemotherapy - MDPI

Despite the fact that there are several different methods of cancer treatments, including radiation therapy, surgery, immunotherapy, endocrine therapy, and gene ...

Mechanisms and insights into drug resistance in cancer - Frontiers

In this review, we discuss different mechanisms adapted by cancerous cells to resist treatment, including alteration in drug transport and metabolism.

Mechanisms of Cancer Drug Resistance - Annual Reviews

Abstract The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective ...

Drug resistance and combating drug resistance in cancer

Mechanisms of intrinsic and acquired resistance described above can co-exist during tumor progression and treatment. Mechanisms of acquired drug resistance can ...

Molecular mechanisms of drug resistance - Pathological Society

Cancer cell resistance to chemotherapy can occur at many levels, including increased drug efflux and decreased drug influx; drug inactivation; ...

Cellular and Molecular Mechanisms of Cancer Drug Resistance

The factors strongly contributing to cancer drug resistance are multiple: mutational processes, epigenetic regulations, cancer stem cells, immune cells, ...

Investigating the mechanisms underlying resistance to ... - Nature

Cancer is one of the major causes of death worldwide and the development of multidrug resistance (MDR) in cancer cells is the principal ...

Why Do Cancer Treatments Stop Working? - NCI

Another approach is to treat patients with drugs that block the particular mechanism of resistance their tumors have developed, and then ...

Drug Resistance in Cancer: Mechanisms and Models - ATCC

The most common method for generating a drug-resistant cancer cell line involves repeated treatment of the cells with clinically relevant anticancer drugs for ...

[PDF] Mechanisms of cancer drug resistance. | Semantic Scholar

The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer ...