The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated ...

In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity.

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we ...

(PDF) The Distinct Roles of Sialyltransferases in Cancer Biology and ...

The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this ...

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sialic Acids / Sialyltransferases / Selectins / Sialic Acid Binding ...

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on ...

https://www.frontiersin.org/journals/immunology/articles/10.3389 ...

... sialyltransferases and may also depend on the type of tumor (see below). Given the significance of distinct sialylation patterns for cancer biology and ...

Insights into the role of sialylation in cancer progression and ...

Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to growing glycoconjugate chains—and the ...

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

The critical role of enzymes that regulate sialic acid in tumour cell growth and metastasis points towards targeting sialylation as a potential new anti- ...

Recent advances in the development of sialyltransferase inhibitors ...

Once the tumor cells are mobilized, sialylated glycans hijack the natural killer T-cells through self-molecular mimicry and activatea downstream cascade of ...

Sialic acids in cancer biology and immunity - Oxford Academic

These changes have been shown to be the result of altered sialyltransferase and sialidase expression. Functionally, cancer-associated hypersialylation appears ...

Recent advances in understanding the roles of sialyltransferases in ...

Abnormal sialylation on the surface of tumor cells is related to tumor migration and invasion, with abnormal expression of sialyltransferases being one of the ...

The role of sialylation in gynecologic cancers - ScienceDirect.com

Sialylated integrins reduce the linkage to ECM and cause tumor mass instability and tumor spreading [7,30]. Selectins are a group of carbohydrate-binding ...

[PDF] Sialic acids in cancer biology and immunity. - Semantic Scholar

Functionally, cancer-associated hypersialylation appears to directly impact tumor cell interaction with the microenvironment, in particular the modulation ...

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco ...

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the ...

499 Sialyltransferases functions in cancers - IMR Press

Abnormally elevated levels of sialylated tumor associated carbohydrate antigens are frequently described at the surface of cancer cells and/or secreted in ...

Sialylation: an Avenue to Target Cancer Cells | Semantic Scholar

The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology · Medicine, Biology. Frontiers in Immunology · 2021.

ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1 ...

We demonstrate that ST3Gal1 plays an important role in modulating tumour immune evasion through the synthesises of sialoglycans with the ...

Hypersialylation and multiple myeloma - Frontiers

Tumor conditioning led to upregulation of sialyltransferases, increases in cell surface sialic acids and expression of Siglec-E ligands. Siglec-E is the murine ...

Sialyltransferases and Neuraminidases: Potential Targets for ... - MDPI

Through recognition by sialic acid-binding proteins, sialyltransferases play a role in the manufacture of tumor-associated sialoglycans, which ...