The Effects of Clonal Heterogeneity on Cancer Immunosurveillance

Intratumor heterogeneity (ITH) is associated with tumor progression in several clinical and experimental settings and contributes to ...

The effects of clonal heterogeneity on cancer immunosurveillance

Clonally heterogeneous tumors are associated with decreased immunosurveillance and are less responsive to immune checkpoint inhibition.

Its relation to cancer immunosurveillance is complex. Clonally heterogeneous tumors are associated with decreased immunosurveillance and are less responsive to ...

Implications of Tumor Clonal Heterogeneity in the Era of ... - PubMed

Clonal heterogeneity likely has a role in cancer progression, relapse, metastasis, and chemoresistance due to functional differences in genetically unique ...

Impact of cancer evolution on immune surveillance and checkpoint ...

Why or if clonal neoantigens might present a higher quality antigen to the immune system is not certain. In the murine setting, there is evidence that ...

Clonal Heterogeneity and Tumor Evolution: Implications for Cancer ...

One of the fundamental drivers of therapeutic resistance and disease progression is clonal heterogeneity within tumors, which arises from genomic instability, ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

Such constraints arise through resource limitations, immune predation, and adverse growth conditions in the form of tissue hypoxia, acidosis, ...

Tumor heterogeneity and clonal cooperation influence the immune ...

However, when these clonal mutant tumor cells were implanted in vivo into mice, they paradoxically showed improved immune-mediated tumor control ...

The role of tumour heterogeneity and clonal cooperativity in ...

Emerging evidence suggests that intratumour heterogeneity may also influence the anti-tumour immune response. Rapid advances in cancer genome ...

Translational Implications of Tumor Heterogeneity - AACR Journals

Studies like this indicate the likely relevance of tumor heterogeneity in predicting adverse outcomes and the evolution of tumor subclonal ...

Tumour heterogeneity and immune-modulation - ScienceDirect.com

This paper discusses the impact that ITH may have on the host immune response to cancer and therefore the potential for immunotherapeutic ...

Intratumoral heterogeneity and clonal evolution in liver cancer - Nature

We detect different clonal expansion of the adaptive immune system in distant regions of the same tumor. An ITH-based gene signature improves ...

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the ...

We suggest that bold approaches to drug development, harnessing the adaptive properties of the immune-microenvironment while limiting those of ...

Impact of Tumor and Immunological Heterogeneity on the Anti ...

As well as differences in immune infiltration and interaction of immune cell types, there are multiple tumor cell intrinsic factors, such as the secretome, ...

Exploring the impact of immune response on tumor heterogeneity ...

Our findings show that a stronger immune response leads to greater homogeneity in the tumor population, which suggests that enhancing immune response could ...

Heterogeneity of the tumor immune microenvironment and its ...

In addition, tumor heterogeneity has a profound impact on the immune microenvironment. Various types of immune cell types show heterogeneous ...

Cancer stemness, intratumoral heterogeneity, and immune ... - PNAS

Stemness positively correlates with higher intratumoral heterogeneity, possibly by protecting antigenic clones from elimination by the immune system. The ...

Intratumor Heterogeneity and Antitumor Immunity Shape One ...

The immune system, on its part, effectively restricts tumor clonality to avoid excessive ITH (66). We believe that understanding the interplay between these ...

The Effects of Clonal Heterogeneity on Cancer Immunosurveillance

The Effects of Clonal Heterogeneity on Cancer Immunosurveillance · ISSN: 24723428 · DOI: 10.1146/annurev-cancerbio-061521-101910 · Publisher: Annual Reviews.

UVB-Induced Tumor Heterogeneity Diminishes Immune ... - Cell Press

Using phylogenetic analyses and mixing experiments of single-cell clones, we dissect two characteristics of ITH: the number of clones forming ...