The Functional Roles of Lipid Rafts in T Cell Activation

The functional roles of lipid rafts in T cell activation, immune ...

The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by cryo-electronic microscopy in 1980s as cavity, ...

The Functional Roles of Lipid Rafts in T Cell Activation, Immune ...

However, the fully understanding of lipid raft was attributed by the studies of T cell activation, virus entry/budding, and other membrane ...

Lipid rafts and their roles in T-cell activation - ScienceDirect.com

A major function of lipid rafts may be to accumulate signaling molecules and keep them in resting state separated from relevant receptors. A really strong ...

Lipid rafts and T-lymphocyte function: Implications for autoimmunity

In T-lymphocytes, lipid rafts are implicated in signalling from the T-cell antigen receptor (TCR) and in localization and function of proteins residing proximal ...

[PDF] The Functional Roles of Lipid Rafts in T Cell Activation ...

The lipid raft as a unique compartment of the plasma membrane, with biological functions that ensure correct intracellular traffic of proteins and lipids, ...

The role of lipid rafts in T cell antigen receptor (TCR) signalling

Together the data suggest that lipid rafts are important in controlling appropriate protein interactions in resting and activated T cells, and that aggregation ...

Membrane Rafts in T Cell Activation: A Spotlight on CD28 ... - Frontiers

Experimental evidence accumulated during the following years, indicated that in real cell membranes transmembrane, signaling, and cytoskeletal proteins play a ...

Structure and function of lipid rafts in human activated T cells

Abstract. Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling ...

Synthetic lipid rafts formed by cholesterol nano-patch induce T cell ...

The coalescence of small lipid rafts into a large lipid raft forms a signaling platform at the immunological synapse that plays a crucial role ...

Transcriptional Regulation of T-Cell Lipid Metabolism - Frontiers

Signaling molecules accumulate at high density in lipid rafts and they are essential for immune cell activation and function (5, 6). Cholesterol helps to ...

CD4 and CD8 T cells require different membrane gangliosides for ...

Initial events of T-cell activation involve movement of the T-cell receptor into lipid rafts. Gangliosides are major components of lipid rafts.

The role of lipid rafts in signalling and membrane trafficking in T ...

T cell activation induces a rapid compartmentalisation of signalling machinery into reorganised rafts that are used as platforms for the ...

T‐cell antigen receptor triggering and lipid rafts - EMBO Press

By promoting temporary lateral confinement, raft nanodomains might contribute to the formation of molecular assemblies, especially those based ...

Lipid rafts in immune signalling: current progress and future ...

Lipid raft-associated adaptor proteins LAT and non-T cell activation linker (NTAL) act as the positive and negative regulators of FcεRI ...

Structure and function of lipid rafts in human activated T cells

In fact,. GM3 is the major ganglioside on the plasma membrane of human peripheral blood lymphocytes and appears to play a functional role in raft-mediated T ...

Lipid rafts: cell surface platforms for T cell signaling - SciELO Chile

Recent data show that the key phosphoinositide PI(4,5)P2 is concentrated in T cell lipid rafts and that on stimulation of the cells it is rapidly converted to ...

Full article: Lipid rafts in T cell receptor signalling (Review)

A current theory that describes early signalling events incorporates the function of lipid rafts, microdomains at the plasma membrane with distinct lipid and ...

Talking Point on the involvement of lipid rafts in T‐cell activation

During the past decade, the lipid‐raft hypothesis has focused attention on the role of membrane domains in controlling cellular functions.

The Functional Roles of Lipid Rafts in T Cell Activation, Immune ...

In this review, we will discuss cholesterol-sphingolipid floating microdomain, the lipid raft as a unique compartment of the plasma membrane, with biological ...

Lipid rafts and their roles in T-cell activation - OUCI

Horejsi, The roles of membrane microdomains (rafts) in T cell activation, Immunol. · Brown, Structure and function of sphingolipid- and cholesterol-rich membrane ...