The Gene That Explains Statins' Most Puzzling Side Effect

Statins, one of the most extensively studied drugs on the planet, taken by tens of millions of Americans alone, have long had a perplexing side ...

Gene variant linked to statin side effect - NBC News

Scientists may have found a way to test for and possibly avoid the most serious side effect of cholesterol-lowering statin drugs, one of the top ...

Muscle problems caused by statins: Can a genetic test reveal your ...

Using genetic material from a small sample of your saliva, the test analyzes a gene called SLCO1B1. Variants in this gene, which affects a ...

Role of genetics in the prediction of statin-associated muscle ...

Biological mechanisms of statin-associated muscle symptoms (SAMS) implicated by genetics. A loss-of-function variant in the SLCO1B1 gene, which encodes a ...

In bid to cure rare disease, scientists discover treatment for statin ...

The reduction in HMG CoA reductase in turn leads to a lack of its normal product, a substance called methylmevalonolactone (mevalonate). Having ...

Statin Toxicity | Circulation Research - AHA Journals

UDP glucuronosyltransferases convert the lactone form of statins to the acid form via a glucuronidation process. SNPs in the UGT1A gene (UGT1A1* ...

Researchers solve mystery of how statins improve blood vessel health

ATAC-seq revealed that simvastatin-treated cells had closed chromatin structures that reduced the expression of genes that cause the endothelial ...

"America's Most Popular Drug [Statins] Has a Puzzling Side Effect ...

"America's Most Popular Drug [Statins] Has a Puzzling Side Effect [Muscle Weakness]. We Finally Know Why." (HMG-CoA mutation for enzyme that ...

Statin side effects: Weigh the benefits and risks - Mayo Clinic

A "nocebo" effect means people who have negative expectations about a medicine report experiencing the potential side effect at higher rates ...

America's Most Popular Drug Has a Puzzling Side Effect. We Finally ...

America's Most Popular Drug Has a Puzzling Side Effect. We Finally Know Why. - Read online for free. Statins, one of the most extensively ...

Genetic factors affecting statin concentrations and subsequent ...

This review evaluated the evidence for a genetic contribution to SRM, the most common side effect in this widely used class of drugs. Among all the loci ...

America's Most Popular Drug Has a Puzzling Side Effect. We Finally ...

They didn't set out to study statins. They weren't studying cholesterol at all. They were hunting for genes behind a rare disease called ...

Statins Puzzling Side Effects - Consensus Academic Search Engine

These studies suggest that while statins are generally safe and effective in reducing cardiovascular risk, they may cause side effects such as ...

America's Most Popular Drug Has a Puzzling Side Effect. We Finally ...

The reason statins can make your muscles sore or weak was unclear—until scientists accidentally stumbled upon an answer. Statins, one of the ...

Statin-associated muscle symptoms: impact on statin therapy ...

Statin-associated myopathy, with significant elevation of serum creatine kinase (CK), is a rare but serious side effect of statins, affecting 1 per 1000 to 1 ...

3 Top Statin Myths Debunked - AARP

The truth about side effects — and how to get more out of these cholesterol-lowering medications · REALITY: Statins can increase the risk of ...

Gene responsible for statin-induced muscle pain identified

Their results showed that atrogin-1 expression was significantly higher among the statin users. Next, the scientists studied statins' effects on ...

Kirsty Woods on LinkedIn: America's Most Popular Drug Has a ...

Kirsty Woods' Post · America's Most Popular Drug Has a Puzzling Side Effect. We Finally Know Why. — The Atlantic · Explore topics · Sign in to view ...

Statin-associated muscle symptoms: - Radboudumc

However, the most common side effect of statins are muscle symptoms, like myalgia, myopathy, and rhabdomyolysis. These muscle symptoms are collectively referred ...

Sarah Zhang on X: "Statins—one of the most popular drugs on the ...

Statins—one of the most popular drugs on the planet—have long had a puzzling side effect: muscle aches, pains, and weakness.