The Genetics of Glaucoma
Glaucoma is the term used for a group of diseases that irreversibly damage the optic nerve, leading to vision loss and ultimately, if untreated, blindness.
Genetic and genomic studies, including genome-wide association studies (GWAS) have accelerated the discovery of genes contributing to glaucoma, ...
Glaucoma: What is Your Genetic Risk? | BrightFocus Foundation
Mutations in CYP1B1 and LTBP2 genes can lead to glaucoma inherited in an “autosomal recessive” fashion where both parents are carriers of the ...
Genetic Etiologies of Glaucoma - JAMA Network
Nanophthalmos can be inherited as an autosomal-recessive or autosomal-dominant trait, and affected patients are at risk for angle-closure glaucoma. One gene, ...
Genetics and Glaucoma: the state of the art - Frontiers
This present review aims to summarize the main achievement in genetic studies of glaucoma, mainly focusing on glaucoma-causing genes.
Common and Rare Genetic Risk Factors for Glaucoma - PMC
Early-onset forms of glaucoma affecting children and young adults are typically inherited as Mendelian autosomal dominant or recessive traits.
Chapter 11. The Genetics of Glaucoma - EyeRounds
Several lines of evidence indicate that glaucoma has a genetic basis, that is, glaucoma is caused in part by defects in specific genes.
Glaucoma and Genetics: Is It Inherited? - Healthline
In some cases, glaucoma has a genetic component. Having a parent or other close relative with glaucoma can also increase your risk of developing it.
Early-onset glaucoma: MedlinePlus Genetics
Early-onset glaucoma is when the disorder appears before the age of 40. Explore symptoms, inheritance, genetics of this condition.
Study profile: the Genetics of Glaucoma Study | BMJ Open
We established the Genetics of Glaucoma Study (GOGS) to identify disease genes and improve genetic prediction of glaucoma risk and response to treatment.
Research is revealing much about the inheritance of disease. Genetic testing is useful for patients with early-onset glaucoma and for some families.
Molecular Genetics of Glaucoma: Subtype and Ethnicity ... - MDPI
This review synthesizes the current literature on glaucoma and genetics, as stratified by glaucoma subtype and ethnicity.
Primary open angle glaucoma genetics: The common variants and ...
In this review we summarize the most common variants reported thus far and their possible clinical correlations.
Glaucoma Genetics: When Is Testing Warranted?
Testing for early-onset glaucoma. Mutations in 6 genes (MYOC, PITX2, FOXC1, PAX6, CYP1B1, and LTBP2) can cause early-onset glaucoma (congenital ...
Genetics of Glaucoma - QIMR Berghofer
By collecting DNA from more people with glaucoma (or glaucoma family history), we can build a more accurate genetic predictor of this disease. For people placed ...
Mutation Analysis of Seven Known Glaucoma-Associated Genes in ...
In this study, whole-exome sequencing was used to screen variations in the seven genes mentioned above in 257 unrelated Chinese patients with primary glaucoma.
Understanding the genetics of glaucoma
Many genes and polymorphisms have been identified as being associated with glaucoma, predicting progression, identifying those at increased risk and allowing ...
Is glaucoma hereditary? - MedicalNewsToday
POAG is hereditary. If members of a person's immediate family have glaucoma, they are at higher risk of developing it themselves. Researchers ...
Review Molecular genetics in glaucoma - ScienceDirect.com
This review examines the current status of genetic investigations of POAG, ACG, XFG, including the less common forms of glaucoma primary congenital glaucoma ( ...
The genetics of primary open-angle glaucoma: A review
Primary open-angle glaucoma (POAG), as the most prevalent form of glaucoma, is a complex inherited disorder and affects more than 2 million individuals in the ...