The Interaction of Porcine Dihydropyrimidine Dehydrogenase with ...

Dihydropyrimidine dehydrogenase (DPD) is a complex enzyme that reduces the 5,6-vinylic bond of pyrimidines, uracil, and thymine.

5-Ethynyluracil (5EU) covalently inactivates DPD by cross-linking with the active-site general acid cysteine in the pyrimidine binding site.

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with ...

Dihydropyrimidine dehydrogenase (DPD) is a complex enzyme that reduces the 5,6-vinylic bond of pyrimidines, uracil and thymine. 5-Fluorouracil (5FU) is also a ...

PDB 7ljt structure summary ‹ Protein Data Bank in Europe (PDBe ...

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. Forouzesh DC, Beaupre BA, Butrin ...

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with ...

Dihydropyrimidine dehydrogenase (DPD) is a complex enzyme that reduces the 5,6-vinylic bond of pyrimidines, uracil, and thymine. 5-Fluorouracil (5FU) is ...

PDB 7ljs structure summary ‹ Protein Data Bank in Europe (PDBe ...

7ljs: The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil.

Porcine recombinant dihydropyrimidine dehydrogenase - PubMed

Dihydropyrimidine dehydrogenase catalyzes, in the rate-limiting step of the pyrimidine degradation pathway, the NADPH-dependent reduction of uracil and ...

7LJS: Porcine Dihydropyrimidine dehydrogenase (DPD) complexed ...

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil. · Electron Density · Validation ...

An improved method for the expression and purification of porcine ...

Improved purification of heterologously expressed porcine dihydropyrimidine dehydrogenase. ... The addition of flavin cofactors during cell lysis increases ...

7LJT: Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked ...

5-Ethynyluracil (5EU) covalently inactivates DPD by cross-linking with the active-site general acid cysteine in the pyrimidine binding site.

7ljs - Porcine Dihydropyrimidine dehydrogenase (DPD) complexed ...

Porcine Dihydropyrimidine dehydrogenase (DPD) complexed with 5-Ethynyluracil (5EU) - Open Form ; Descriptor, Dihydropyrimidine dehydrogenase [NADP(+)], IRON/ ...

Purification, Characterization, and Kinetics of Porcine Recombinant ...

Porcine recombinant dihydropyrimidine dehydrogenase was purified fromEscherichia colicells using cell disruption, ammonium sulfate fractionation, and ...

7ljt - Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked with ...

Porcine Dihydropyrimidine Dehydrogenase (DPD) soaked with 5-Ethynyluracil (5EU), NADPH - 20 minutes ; Functional Keywords, dihydropyrimidine dehydrogenase, dpd, ...

An improved method for the expression and purification of porcine ...

Dihydropyrimidine dehydrogenase (DPD) catalyzes the reduction of uracil and thymine bases with electrons derived from NADPH. The mammalian DPD enzyme is a ...

ﬁsulfur clusters in the complex redox enzyme dihydropyrimidine ...

Porcine liver dihydropyrimidine dehydrogenase is a homodimeric iron±sulfur flavoenzyme that catalyses the first and rate-limiting step of pyrimidine ...

Crystal structure of dihydropyrimidine dehydrogenase, a major ...

The non‐classical two‐site ping‐pong kinetic mechanism of the pig liver enzyme suggests two separate binding sites for the substrates NADPH/NADP+ and pyrimidine ...

Full article: Purification and characterization of dihydropyrimidine ...

DPD catalyses the NADPH-dependent reduction of uracil and thymine to 5,6-dihydrouracil and 5,6-dihydrothymine, respectivelyCitation1. In addition, DPD degrades ...

On the iron–sulfur clusters in the complex redox enzyme ...

Porcine liver dihydropyrimidine dehydrogenase is a homodimeric iron–sulfur flavoenzyme that catalyses the first and rate-limiting step of ...

Mammalian dihydropyrimidine dehydrogenase: Added mechanistic ...

Forouzesh, The interaction of porcine dihydropyrimidine dehydrogenase with the chemotherapy sensitizer: 5-ethynyluracil, Biochemistry, № 60, с. 1120 https ...

Dali Liu - SelectedWorks

The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer ... American Chemical Society (2021). Dali Liu. Dihydropyrimidine ...