The Lactate and the Lactate Dehydrogenase in Inflammatory ...

Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of anaerobic glycolysis with end product of lactate from ...

Both blood LDH and blood lactate are suggested as risk factors for the mortality of patients in serious inflammatory diseases.

Role of Lactate in Inflammatory Processes: Friend or Foe - Frontiers

During an inflammatory process, shift in the cellular metabolism associated with an increase in extracellular acidification are well-known features. This pH ...

Inhibition of lactate dehydrogenase A suppresses inflammatory ...

In this study, we investigated whether the inhibition of LDHA has anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages.

Lactate dehydrogenase - Wikipedia

Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells. LDH catalyzes the conversion of pyruvate to lactate and back, ...

AB0532 LACTATE DEHYDROGENASE AS A PREDICTOR OF ...

High lactate levels are a marker of inflammation and create a pro-inflammatory microenvironment[2]. LDH levels can be raised in myositis, haemolysis and ...

Lactate Dehydrogenase - an overview | ScienceDirect Topics

Lactate dehydrogenase (LDH) is the key enzyme that catalyzes the conversion between lactate and pyruvate in the presence of nicotinamide adenine nucleotide ( ...

Lactate at the crossroads of metabolism, inflammation, and ...

Taken together, lactate plays an important role in inducing and promoting inflammation and in the modulation of immune cell functions. Targeting ...

Usefulness of lactate dehydrogenase and its isoenzymes as ...

This review describes the usefulness of monitoring the activity level of lactate dehydrogenase (LDH) and its isoenzyme pattern as indicators of pathological ...

Serum lactate dehydrogenase activities as systems biomarkers for ...

The method to analyze serum LDH activities is a spectrophotometry-based analysis. LDH catalyzes a reversible conversion of lactate to pyruvate ...

Lactate Dehydrogenase as a Measure of Inflammation in ...

A reliable animal model for acute otitis media due to Streptococcus pneumoniae was used to study the accumulation of lactate dehydrogenase (LDH) in.

Lactate Dehydrogenase - an overview | ScienceDirect Topics

Lactate dehydrogenase is an enzyme that converts pyruvate to lactate and vice versa, while also converting NADH to NAD. It plays a role in energy production ...

Lactate dehydrogenase, an independent risk factor of severe COVID ...

Meanwhile, prolonged prothrombin time (PT) and elevated lactate dehydrogenase (LDH) was found in more than 40% cases during the whole disease period [5, 7], ...

Serum lactate dehydrogenase predicts prognosis and correlates ...

Further, evidence indicates that HIF-1 promotes inflammation and fibrosis in patients with PDAC, indicating a correlation between hypoxia and ...

Examining the association between serum lactic dehydrogenase ...

25 These observations provided strong evidence that serum LDH was closely associated with inflammation. In our study, LDH may be as a systemic inflammatory ...

Systemic inflammatory markers and serum lactate dehydrogenase ...

Preoperative LDH, CRP, NLR, PLR, and LMR have significant prognostic value in patients with WT independently of age and stage.

Rap1b-loss increases neutrophil lactate dehydrogenase activity to ...

Discussion: Acidic milieu renders neutrophils more dependent on Ldha activity such that their effector functions are more readily inhibited by ...

Serum LDH in chronic cough: a potential marker of airway ...

Lactate dehydrogenase (LDH) is an intracellular cytoplasmic enzyme found in abundance in most cells of the human body. It catalyses the final ...

"Renal Lactate Dehydrogenase A: Underlying Mechanisms and ...

Lactate Dehydrogenase A (LDHA) plays a major role in the aerobic glycolytic switch that is a key process in both M1 macrophage polarization and renal tubular ...

Elevated Lactate Dehydrogenase (LDH) level as an independent ...

It has been reported that elevated serum LDH levels are associated with poor prognosis in various diseases, especially in tumors and inflammation [4–6]. To date ...