The Link between Mitochondrial Dysfunction and Sarcopenia

Muscle from patients with chronic kidney disease shows mitochondrial dysfunction, with increased PDK4-mediated PDC inactivation and distorted dynamics resulting ...

Previous studies showed that mitochondrial dysfunction arising from the abnormal accumulation of mitochondrial DNA (mtDNA) induced the early appearance of ...

Mitochondrial involvement in sarcopenia - Wiley Online Library

... disorders that are linked to the functional decline of various organs. ... dysfunction have been implicated in different types of sarcopenia ...

Linking mitochondrial dysfunction to sarcopenia - ScienceDirect.com

The decline of mitochondrial function with aging appears to precede sarcopenia, and increasing mitochondria dysfunction increases sarcopenia once it begins [74] ...

Mitochondrial Quality Control in Sarcopenia - Aging and disease

At the cellular and molecular levels, a constellation of latent mechanisms have been shown to participate in the sarcopenia, such as mitochondrial dysfunction[ ...

Exercise and mitochondrial mechanisms in patients with sarcopenia

There is evidence that mitochondrial dysfunction is an important cause of sarcopenia. Oxidative stress and reduction of antioxidant defenses in ...

Mitochondrial disorders as a mechanism for the development of ...

... mitochondrial autophagy disorder, which proves the relationship between mitochondria and obese sarcopenia. ... dysfunction and sarcopenia of ...

Mitochondrial dysfunction and sarcopenia of aging: From signaling ...

Periodical assessments of muscle mitochondrial function may allow detecting early signs of dysfunction. Once the presence of sarcopenia has been established, ...

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Understanding the pathogenesis of mitochondrial dysfunction is useful for the prevention and treatment of skeletal muscle atrophy, and finding ...

Mitochondrial oxidative capacity and NAD+ biosynthesis are ...

For the first time we demonstrate that mitochondrial bioenergetic dysfunction is the strongest molecular signature of sarcopenia in three ...

Update on mitochondria and muscle aging: all wrong roads lead to ...

Regardless of the actual role of mitochondrion-generated ROS, mitochondrial dysfunction has been listed among the hallmarks of aging (Lopez-Otin ...

The Interplay between Mitochondrial Morphology and Myomitokines ...

Its dysfunction is a major determinant of poor prognosis and reduced quality of life. Sarcopenia is an age-related skeletal muscle disease recognized by the ...

Mitochondrial dysfunction and sarcopenia of aging - ResearchGate

Sarcopenia, the age-related decline in muscle mass and function, is thought to be driven by multiple processes, with mitochondrial dysfunction in skeletal ...

Mitochondrial Quantity and Quality in Age-Related Sarcopenia - MDPI

The second may be due to energy shortage consequent to sustained mitochondrial dysfunction that hampers the energetically expensive mitophagy execution.

[PDF] Role of Age-Related Mitochondrial Dysfunction in Sarcopenia

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. · Resistance training, sarcopenia, and the mitochondrial theory of ...

Unraveling the causes of sarcopenia: Roles of neuromuscular ...

Mitochondrial dysfunction and increased ROS production in aged muscle have been identified as two key factors contributing to NMJ deterioration ...

From mitochondria to sarcopenia: role of 17β-estradiol and ...

Another primary cause of mitochondrial dysfunction in aging muscle is the impaired mitochondrial autophagy (mitophagy) machinery. Mitophagy is a particular type ...

The Link between Mitochondrial Dysfunction and Sarcopenia

Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience.

Linking mitochondrial dysfunction to sarcopenia - OUCI

Linking mitochondrial dysfunction to sarcopenia. https://doi.org/10.1016/b978 ... Atmis, The relationship between all-cause mortality sarcopenia and ...

(PDF) Mitochondrial Impairment in Sarcopenia - ResearchGate

Thus, mitochondrial dysfunction contributes significantly to the complex pathogenesis of sarcopenia, and mitochondria are indicated as potential ...