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The Pathogenesis of Systemic Lupus Erythematosus – An Update


The pathogenesis of systemic lupus erythematosus-an update

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to ...

The Pathogenesis of Systemic Lupus Erythematosus – An Update

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to ...

The pathogenesis of systemic lupus erythematosus—an update

This review will focus upon recently dissected biologic events that provide insight into disease pathogenesis in three major areas.

Pathogenesis of systemic lupus erythematosus: risks, mechanisms ...

The systemic nature of SLE reflects the widely distributed alterations in immune system activity that result in autoimmunity targeting nucleic acids and their ...

The pathogenesis of systemic lupus erythematosus—an update

Highlights ▻ Innate effectors are critical for the lupus phenotype. ▻ Aberrant adaptive immune responses promote disease progression in SLE.

Systemic lupus erythematosus - The Lancet

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterised by the presence of autoantibodies towards nuclear antigens.

Advances in the Pathogenesis and Treatment of Systemic Lupus ...

The pathogenesis of SLE is complex and involves cells of both innate and adaptive immunity. The distinguishing feature of SLE is the production of ...

Pathogenesis of systemic lupus erythematosus

SLE is characterised by a myriad of immune system aberrations that involve B cells, T cells, and cells of the monocytic lineage, resulting in polyclonal B cell ...

Systemic lupus erythematosus: Epidemiology and pathogenesis

RELATED TOPICS · Patient education: Systemic lupus erythematosus (Beyond the Basics) · An overview of the innate immune system · Antibodies to ...

Immunometabolism in the pathogenesis of systemic lupus...

Systemic lupus erythematosus (SLE) is a highly heterogenous autoimmune syndrome characterized by immune dysregulation that promotes the generation of ...

Pathogenesis of systemic lupus erythematosus update - Pathology

pDCs polarise T cells through its high production of IFN-a, the central cytokine that contributes to SLE development. Elevated serum levels of IFN-a correlate ...

Systemic lupus erythematosus: latest insight into etiopathogenesis

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown etiology. Multifactorial interaction among various susceptible factors

Update on the pathophysiology of systemic lupus erythematosus

This review will discuss the series of events involved in the break-down of immune tolerance in SLE, followed by immune complex formation, ...

The pathogenesis of systemic lupus erythematosus—an update

Highlights ▻ Innate effectors are critical for the lupus phenotype. ▻ Aberrant adaptive immune responses promote disease progression in SLE.

Systemic Lupus Erythematosus (SLE) - Medscape Reference

Whether polyclonal B-cell activation or a response to specific antigens exists is unclear, but much of the pathology involves B cells, T cells, ...

Disentangling the Pathogenesis of Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease that attacks various organ systems with a variety of clinical implications, ranging from ...

An Overview of Systemic Lupus Erythematosus (SLE) Pathogenesis ...

In SLE, an imbalanced T cell cytokine profile characterized by decreased IL2 leads to impaired Treg cell development and function [18]. Reduced ...

Lupus | Pathogenesis and Pathophysiology - Healio

In many ways, SLE is a prototype autoimmune disease, with involvement of both innate and adaptive system components in an inappropriate response ...

T Cell Abnormalities in the Pathogenesis of Systemic Lupus ...

Systemic lupus erythematosus is a complex disease with broad spectrum of clinical manifestations. In addition to abnormal B cell responsive ...

Systemic lupus erythematosus | Nature Reviews Disease Primers

The role of SLE autoantibodies in the pathogenesis of the disease has traditionally focused on deposition of immune complexes in the skin, the ...