The Primary Outcome Fails

The Primary Outcome Fails — What Next?

When a trial is too small to detect modest treatment effects, it is appropriate to describe the findings as inconclusive rather than negative.

The Primary Outcome Fails - What Next? - PubMed

The Primary Outcome Fails - What Next?

The changing face of clinical trials: The primary outcome fails—What ...

This article provides an overview of what will happen if the primary outcome fails in the clinical trials. When the primary outcome of a trial fails to ...

The Primary Outcome Fails — What Next? | NEJM

Abstract. When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information ...

Primary outcome fails - what next? - First10EM

Primary outcome fails – what next? · Is there some indication of potential benefit? · Was the trial underpowered? · Was the primary outcome appropriate (or ...

The Primary Outcome Fails — What Next? - OneSearch

When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information still be derived from it?

The Primary Outcome Fails — What Next? | Request PDF

... We considered analyses on secondary outcomes as hypothesis generating [45]. Trials were 'potentially beneficial' if change in the primary trial outcome was ...

The Primary Outcome Fails — What Next? - Aurora University (ARU)

When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information still be derived from it?

The Primary Outcome Fails - What Next? - LSHTM Research Online

Copy Pocock, Stuart J; Stone, Gregg W; (2016) The Primary Outcome Fails - What Next? The New England journal of medicine, 375 (9). pp. 861-870.

Why a Missed Primary Endpoint Isn't the End of the Road

What often happens is argument over whether negative primary endpoint results should be ignored in favor of secondary outcomes.

The Primary Endpoint Is Negative: What Happens Now? - Medscape

With the 12 points I have taken you through, I can assist you in deciding what to do next when a trial's primary outcome results seem to have ...

The Primary Outcome Measure and Its Importance in Clinical Trials

The primary outcome is then selected by expert consensus or by following conventional practice. After the study is completed and the data are ...

Primary and Secondary Outcome Reporting in Randomized Trials

There may be additional safety outcomes and exploratory outcomes, but key to interpretation of trial findings is the primary outcome and the ...

Why have status epilepticus trials failed: Wrong drugs or wrong trials?

A Focus on Evaluating Major Study Limitations in Order to Apply ...

The primary outcome should be specified prior to study commencement, and any secondary outcomes ... The primary outcome fails—what next? N Engl J Med. 2016;375(9): ...

Why clinical trial outcomes fail to translate into benefits for patients

We highlight problems with trial outcomes that make evidence difficult or impossible to interpret and that undermine the translation of research into practice ...

The Primary Outcome Fails – What Next? – AMD

The Primary Outcome Fails – What Next? ... AMD segnala articoli della letteratura internazionale la cui rilevanza e significato clinico restano aperti alla ...

Could do better: clinical trial reporting fails to live up to the mark

The statistical analysis and reporting of treatment effects in reports of randomised trials with a binary primary endpoint requires substantial improvement.

Why have status epilepticus trials failed - Epilepsy & Behavior

Questions to ask when the primary outcome fails. Is there some ... The primary outcome fails - what next? N Engl J Med 2016;. 375:861–70 ...

Strategies for Reporting of Primary and Secondary Outcomes in ...

The primary outcome is positive - Is that good enough? N Engl J. Med 2016;375:971–79. 3. Pocock SJ, Stone GW. The primary outcome fails - What next? N Engl J ...