The RET proto|oncogene in human cancers

The RET proto-oncogene in human cancers - Nature

The RET proto-oncogene was identified as the susceptibility gene for multiple endocrine neoplasia type 2 (MEN 2), an inherited cancer syndrome ...

The RET proto-oncogene in human cancers - PubMed

The activation of the RET proto-oncogene contributes to the development of human cancers in two different ways. Somatic rearrangements of RET with a variety ...

RET proto-oncogene in the development of human cancer - PubMed

RET proto-oncogene in the development of human cancer ... There appears to be a correlation between specific RET mutation type and organ-specific tumor ...

Roles of the RET Proto-oncogene in Cancer and Development

To date, RET fusion with other partner genes has been reported in a variety of human cancers, including papillary thyroid carcinoma (PTC) (22), (23), (24) and ...

RET Proto-Oncogene in the Development of Human Cancer

RET Proto-Oncogene in the Development of Human Cancer. Author ... RET oncogene mutations in a large Korean kindred with familial medullary thyroid carcinoma.

RET Proto-Oncogene - an overview | ScienceDirect Topics

The RET proto-oncogene was identified as the causative gene for human papillary thyroid carcinoma, multiple endocrine neoplasia (MEN) types 2A and 2B, and ...

RET Proto-Oncogene in the Development of Human Cancer

Somatic (tumor-specific) mutations in RET have also been found in a variety of sporadic tumors. RET PROTO-ONCOGENE. The RET proto-oncogene, localized to ...

RET signaling pathway and RET inhibitors in human cancer - Frontiers

While RET fusions are detected in other cancers, such as breast cancer and salivary gland carcinomas (discussed later), RET fusions occur in these cancer types ...

RET Proto-Oncogene—Not Such an Obvious Starting Point ... - MDPI

Papillary thyroid carcinoma and non-small cell lung cancer are not the only neoplasms that present RET rearrangements. These aberrations are also detected in ...

Inherited cancers associated with the RET proto-oncogene

32. T. Koda. Ret Gene from a Human Stomach Cancer. Hokkaido J Med Sci, 63 (1988), ...

RET proto-oncogene - Wikipedia

... cancers, which prompted an FDA approval for both these indications in May 2020. ... "Exon structure and flanking intronic sequences of the human RET proto- ...

RET gene: MedlinePlus Genetics

Health Conditions Related to Genetic Changes · Nonsyndromic paraganglioma · Hirschsprung disease · Multiple endocrine neoplasia · Lung cancer · Other cancers.

[PDF] The RET proto-oncogene in human cancers - Semantic Scholar

306 Citations · The RET proto‐oncogene: A molecular therapeutic target in thyroid cancer · RET Signaling in Endocrine Tumors: Delving Deeper into Molecular ...

Minireview: RET: Normal and Abnormal Functions - Oxford Academic

RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. ... The RET proto-oncogene in human cancers. Oncogene. 19. : 5590. –.

REThinking the role of the RET oncogene in breast cancer - Frontiers

RET signaling pathway and RET inhibitors in human cancer. Front ... RET proto-oncogene for breast carcinoma. Clin Cancer Res. (2015) 21 ...

RET gene - MedlinePlus

These tumors can be noncancerous or cancerous. Multiple endocrine neoplasia type 2 is divided into three subtypes: type 2A, type 2B, and ...

The RET oncogene in papillary thyroid carcinoma - Prescott - 2015

Subsequent analysis of human tumors revealed that oncogenic RET ... tumor always occurs in intron 11 of the RET proto-oncogene. The ...

RET Aberrations in Diverse Cancers: Next-Generation Sequencing ...

Analysis of RET aberrations among diverse cancers (N = 4,871). Among the 4,871 diverse cancer patients, the most common diagnosis was breast carcinoma [10.4% ( ...

Selective repression of RET proto-oncogene in medullary thyroid ...

In accordance with the pivotal role of RET in regulating the growth of thyroid cancer cells in tumor development, there are clinically available ...

RET as a Diagnostic and Therapeutic Target in Sporadic and ...

On the other hand, activating RET mutations and rearrangements cause human cancers and cancer syndromes, such as familial medullary thyroid carcinoma (FMTC), ...