The Role of Amyloid|β Oligomers in Toxicity

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and ...

Even though ThT reacts with the prefibrillar oligomers, its strongest association occurs only in the presence of mature fibrils. Amyloid ...

The Role of Amyloid-β Oligomers in Toxicity, Propagation ... - PubMed

The incidence of Alzheimer's disease (AD) is growing every day and finding an effective treatment is becoming more vital. Amyloid-β (Aβ) has ...

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need ...

An alternative hypothesis suggests that small soluble oligomeric structures consisting of amyloid peptides can cause cellular toxicity.

The Toxicity and Polymorphism of β-Amyloid Oligomers - MDPI

It is widely accepted that β-amyloid oligomers (Aβos) play a key role in the progression of Alzheimer's disease (AD) by inducing neuron damage and cognitive ...

Structure–neurotoxicity relationships of amyloid β-protein oligomers

Purified monomers were slightly more toxic than was Aβ alone (≈44% versus ≈35%), although this toxicity difference was not significant statistically. However, ...

Towards an understanding of amyloid-β oligomers - RSC Publishing

Among the various Aβ species, structured oligomers are proposed to be more toxic than fibrils; however, the identification of Aβ oligomers has ...

What are the toxicity-defining properties of amyloid β? - ScienceDirect

Disruption of the neuronal membrane by toxic amyloid β oligomers is hypothesized to be the major event associated with Alzheimer's disease's neurotoxicity.

Amyloid oligomers: formation and toxicity of Aβ ... - FEBS Press

The high toxicity of low-MW Aβ oligomers is also supported by in vitro studies showing that Aβ dimers are threefold more toxic than monomers, ...

Amyloid β-protein oligomers and Alzheimer's disease

The apparent potency of exogenously applied oligomers supports a role for oligomers in AD. An Arctic kindred that develops a familial form of AD ...

Amyloid β Dodecamer Disrupts the Neuronal Membrane More ...

However, recent experiments have shown that Aβ oligomers are more toxic to neurons than highly ordered fibrils. The molecular mechanism ...

Targeting the proper amyloid-beta neuronal toxins: a path forward ...

In contrast, soluble amyloid-beta oligomers are widely reported to be the most toxic amyloid-beta form, both causing acute synaptotoxicity and ...

Toxic amyloid-β oligomers induced self-replication in astrocytes ...

Our results suggest that astrocytes may play a central role in the progression of AD by duplicating and spreading toxic AβOs, thus triggering neuronal injury.

New Alzheimer's disease model mouse specialized for analyzing ...

Oligomers of intracellular amyloid β protein (Aβ) are strongly cytotoxic and play crucial roles in synaptic transmission and cognitive ...

Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers

Herein, we review the recently published finding that cellular prion protein (PrPc) is a high-affinity receptor for Aβ oligomers, mediating their toxic effects ...

Structure of amyloid oligomers and their mechanisms of toxicities

Protein misfolding is one of the leading causes of amyloidoses. · The amyloid oligomers, protofibrils and fibrils show an increasing order of organization. · The ...

Common structure and toxic function of amyloid oligomers implies a ...

Recent evidence suggests that amyloid oligomers have a common structure, suggesting that they all may share a common primary mechanism of pathogenesis.

Oligomerization and Conformational Change Turn Monomeric β ...

Recent results demonstrate that monomeric Aβ has important physiological functions. Toxic oligomeric Aβ assemblies (AβOs) may play a decisive role in AD ...

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive ...

A large body of evidence accumulated in the past 15 years supports a pivotal role of soluble Aβ oligomers (AβOs) in synapse failure and neuronal dysfunction in ...

The biogenesis and biology of amyloid β oligomers in the brain

Although both types of oligomers are toxic, what matters most for how they affect brain function is the way they are distributed in the brain.

Amyloid-β Peptide Nitrotyrosination Stabilizes Oligomers and ...

The nitrated Aβ oligomers are more toxic to neurons due to increased cytosolic calcium levels throughout their action on NMDA receptors.