The Role of DNA Methyltransferase in Stem Cell Aging

Thereby, the epigenetic characteristics of adult stem cells are likely to be more susceptible to DNMTs rather than embryonic stem cells (ESCs) with differential ...

DNA Methyltransferase Controls Stem Cell Aging by Regulating ...

Taken together, DNMTs have a critical role in regulating the cellular senescence of hUCB-MSCs through controlling not only the DNA methylation status but also ...

The Role of DNA Methylation in Aging, Rejuvenation, and Age ...

DNA methylation is a major control program that modulates gene expression in a plethora of organisms. Gene silencing through methylation occurs through the ...

The Role of DNA Methyltransferase in Stem Cell Aging

Epigenetic regulations in adult stem cells: the role of. DNA methyltransferase in stem cell aging. Despite the fact that DNA methyltransferases. (DNMTs) are ...

Aging and DNA methylation | BMC Biology | Full Text - BioMed Central

DNA methylation has become a hallmark of aging, though there is so far no proof that a change in specific DNA methylation patterns can extend ...

DNA methylation controls hematopoietic stem cell aging - Nature

Epigenome deregulation is considered a hallmark of aging; however, the function of the alteration of DNA methylation in aged tissues is a ...

The role of DNA methylation in epigenetics of aging - ScienceDirect

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic role in aging. Epigenetic clocks, which measure changes in a few ...

Progress on the role of DNA methylation in aging and longevity

An abundance of literature indicates that aberrant epigenetic change occurs throughout the aging process at both the cellular and the organismal ...

Ageing affects DNA methylation drift and transcriptional cell ... - Nature

These results indicate that epigenetic drift, by accumulation of stochastic DNA methylation changes in promoters, is associated with the ...

DNA Methylation in Cancer and Aging - AACR Journals

Strikingly, the changes in DNA methylation seen in aging stem cells are very similar to those detected in MDS (14), strongly suggesting that a ...

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging ...

Together, these data suggest that altered DNA methylation may play a role in underwriting the functional decline associated with stem cell aging ...

DNA Methylation Biomarkers in Aging and Age-Related Diseases

It is currently well established that DNA methylation biomarkers can determine biological age of any tissue across the entire human lifespan, ...

Effect of DNA methylation on the osteogenic differentiation of ...

As a stem gene of human induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs), DNMT3B expression level is lower than that of BMSCs, and it ...

DNA methylation entropy as a measure of stem cell replication and ...

Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology ...

Epigenetic Regulation of Bone Marrow Stem Cell Aging

This raises the interesting possibility that altered DNA methylation in HSC during aging requires changes in histone modifications to effect gene expression ...

Proliferation-Dependent Alterations of the DNA Methylation ...

Physiological aging and experimentally enforced proliferation of HSCs both led to DNA hypermethylation of genes regulated by Polycomb Repressive ...

TERT activation targets DNA methylation and multiple aging hallmarks

Here, we report the identification of a TERT activator compound (TAC) that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. In primary human cells ...

Aging and epigenetic drift: a vicious cycle - JCI

Approximately 70%–80% of the DNA methylation abnormalities in cancer can be traced to aging defects (25), and cancer itself can be seen as an accelerated aging ...

The role of DNA methylation in stem cell ageing - UCL Discovery

A number of genes were identified to be significantly age differentially methylated and differentially expressed. One aDMR, associated with the Serum ...

DNA methylation dynamics in cellular commitment and differentiation

The influence of DNA methylation levels in tissue-specific stem cell functions and capacities has been demonstrated by decreasing Dnmts activity ...