The Role of Glutamate Receptors in Epilepsy

The Role of Glutamate Receptors in Epilepsy - PubMed

Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development ...

The Role of Glutamate Receptors in Epilepsy - PMC - PubMed Central

Glutamate, glutamate receptors, and regulation of astrocytes are significantly involved in the pathogenesis of acute seizure and chronic epilepsy. Some ...

Brain concentrations of glutamate and GABA in human epilepsy

This imbalance is related to increased extracellular glutamate in the brain and/or reduction in GABA concentrations, leading to excitotoxicity, seizures, and ...

Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on ...

As noted, direct activation of glutamate receptors can elicit seizures; however, the pathological function of each glutamate receptor in epilepsy is not well ...

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

Glutamate can also in- teract with an additional ionotropic glutamate receptor, the kainate receptor (KAR). The KAR has a less clearly understood role in ...

The Roles of Glutamate Receptors and Their Antagonists in Status ...

According to the findings, glutamate receptors, particularly ionotropic glutamate receptors, may play a substantial role in seizure genesis. Following clinical ...

Global trends in research of glutamate in epilepsy during past two ...

Glutamate mediates most excitatory neurotransmission in the mammalian CNS by activating ionotropic glutamate receptors [N-methyl-D-aspartic acid ...

Glutamate receptors and epilepsy | Protein Data Bank in Europe

Glutamate receptors mediate the majority of excitatory neurotransmission, playing a key role in the generation and spread of epileptic seizures, ...

Glutamate and Epilepsy - ScienceDirect.com

Regardless of the primary cause, synaptically released glutamate acting on ionotropic and metabotropic receptors appears to play a major role in the initiation ...

Gene variations of glutamate metabolism pathway and epilepsy

Glutamate is the most important excitatory neurotransmitter in the brain and plays an important role in epileptogenesis. Mutations in genes at ...

The Role of Glutamate Transporters in Developmental Epilepsy

Therefore the early expression of glutamate transporters plays a central role to prevent the activation by local glutamate concentrations of NMDA receptors and ...

The role of glutamate in epilepsy and other CNS disorders. - Abstract

Glutamate antagonists selective for NMDA or non-NMDA receptors are potent anticonvulsants when given systemically in a wide variety of animal models of epilepsy ...

Dysregulation of Ambient Glutamate and Glutamate Receptors in ...

Questions remain and more work certainly needs to be done to further elucidate the role of mGluRs in epilepsy, however, it appears evident that mGluR expression ...

The Role of Neurotransmitters in Epileptogenesis: Focus on GABA ...

Glutamate levels are known to be elevated in epilepsy patients. Being the primary neurotransmitters for inhibition/excitation of neurons, GABA ...

Glutamatergic Mechanisms Related to Epilepsy: Ionotropic Receptors

A wealth of new pharmacologic reagents, particularly allosteric receptor modulators, have been introduced that can facilitate study of the roles of specific ...

The roles of metabotropic glutamate receptors in seizures and ...

Because of their central role in modulating numerous physiological processes in the central nervous system, metabotropic glutamate receptors (mGluRs) have been ...

Glutamatergic Mechanisms Associated with Seizures and Epilepsy.

Chronic seizures can alter neuronal and glial expression of glutamate receptors and uptake transporters, further contributing to epileptogenesis. Evidence ...

A Review Focusing on AMPA and NMDA Receptors - OUCI

It is widely accepted that glutamate-mediated neuronal hyperexcitation plays a causative role in eliciting seizures. Among glutamate receptors, the roles of ...

Glutamate receptor - Wikipedia

Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate is abundant in the ...

The role of glutamate in epilepsy and other CNS disorders

Anticonvulsant compounds of the lamotrigine type, which act on sodium channels and reduce ischemia-induced glutamate release, are cerebroprotective in ...