The SAGA acetyltransferase module is required for the maintenance ...

The SAGA complex serves as a coactivator in transcription and catalyzes acetylation and deubiquitylation. Analyses of datasets in the Cancer ...

The SAGA acetyltransferase module is required for the ... - PubMed

The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma. Genes Dev. 2024 Sep ...

Results · SAGA-specific ADA2B is a dependency in multiple myeloma · ADA2B is required for maintenance of oncogenic gene expression programs.

The SAGA acetyltransferase module is required for the maintenance ...

Request PDF | On Aug 21, 2024, Ying-Jiun C Chen and others published The SAGA acetyltransferase module is required for the maintenance of ...

The SAGA acetyltransferase module is required for the maintenance ...

Article on The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma., ...

The SAGA acetyltransferase module is required for the maintenance ...

The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma.

The SAGA histone acetyltransferase module targets SMC5/6 to ...

Structural Maintenance of Chromosomes (SMC) complexes are molecular machines driving chromatin organization at higher levels.

The SAGA HAT module is tethered by its SWIRM domain and ...

The histone acetyltransferase (HAT) module, which acetylates multiple lysines on histone H3 tails, contains the catalytic Gcn5 subunit bound to three additional ...

Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase ...

Here, we review the structure and functions of the SAGA deubiquitinase module and regulatory mechanisms acting to control these. Introduction. There is a ...

KAT2A complexes ATAC and SAGA play unique roles in cell ...

... acetyltransferase (HAT) module ... , et al. The lysine acetyltransferase GCN5 is required for iNKT cell development through EGR2 acetylation .

ATAC and SAGA histone acetyltransferase modules facilitate ...

We report HAT module binding to nucleosomes as the S1/2, the concentration of the HAT module required for half of the nucleosomes to be bound.

The SAGA complex regulates early steps in transcription via its ...

Given that in yeast, deubiquitylation of histone H2B by the SAGA DUB module is a necessary step in inducible transcription (Henry et al, 2003; Wyce et al, 2007) ...

Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ...

GCN5/. KAT2A was also identified in a knock down screen of 22. KATs to be selectively required for maintenance of malonyl-. K levels in K562 ...

Role of the SAGA co-activator complex in transcription during cell ...

SAGA and ATAC complexes are required of mouse ES cell maintenance. ATAC but ... Using mouse embryos lacking essential subunits of the DUB module, we ...

Dynamic modules of the coactivator SAGA in eukaryotic transcription

... essential for maintaining the integrity of SAGA) in H. sapiens. In ... Proper expression of the Gcn5 histone acetyltransferase is required for ...

QuickGO::Term GO:0000124

... module and consisting of ADA1 or a homolog, members of the SPT and ... A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B.

Conservation and diversity of the eukaryotic SAGA coactivator ...

GCN5 is the lysine acetyltransferase (KAT) within SAGA, targeting lysines in histones H3 and H2B, and is particularly required for acetylation ...

KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in ...

... required for maintenance of malonyl-K levels in K562 cells (77 ... Structural insights into the assembly and function of the SAGA deubiquitinating module.

Ying-Jiun Chen on LinkedIn: The SAGA acetyltransferase module is ...

I'm happy to share that our paper “The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene ...

The SAGA core module is critical during Drosophila oogenesis and ...

Author summary · The Spt/Ada-Gcn5 Acetyltransferase (SAGA) complex is required for the transcription of most RNA polymerase II (Pol II) genes [ · The modules form ...