The SAGA complex

Conservation and diversity of the eukaryotic SAGA coactivator ...

The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and ...

Dynamic modules of the coactivator SAGA in eukaryotic transcription

SAGA (Spt-Ada-Gcn5 acetyltransferase) is a eukaryotic transcription coactivator complex that controls transcription by modifying histones. The ...

The SAGA chromatin-modifying complex: the sum of its parts is ...

The SAGA complex contains TBP-associated factors. Transcription initiation requires the assembly of the preinitiation complex (PIC), formed by ...

Structure of the human SAGA coactivator complex - Nature

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling.

The SAGA coactivator complex acts on the whole transcribed ...

discovered that SAGA acetylates the promoters and deubiquitinates the transcribed region of all expressed genes. SAGA also plays a critical role for RNA ...

SAGA Complex - The Nogales Lab

SAGA has been functionally implicated in a multitude of cellular pathways, from serving as a regulatory hub in transcription to its involvement in cell ...

Transcription Factor SAGA - an overview | ScienceDirect Topics

2.1 SAGA complex composition. SAGA is a chromatin-modifying transcriptional co-activator complex of 21 proteins which was first discovered in yeast to be then ...

SAGA complex | SGD - Saccharomyces Genome Database

The Saccharomyces Genome Database (SGD) provides comprehensive integrated biological information for the budding yeast Saccharomyces cerevisiae.

The SAGA complex regulates early steps in transcription via its ...

We report here that human USP22 contributes to the early stages of stimulus‐responsive transcription, where USP22 is required for pre‐initiation complex (PIC) ...

Multiple faces of the SAGA complex - ScienceDirect.com

Although first discovered and characterized as a HAT complex, SAGA was later discovered to harbor a second catalytic module centered on the Ubp8 (yeast) or ...

The KAT module of the SAGA complex maintains the oncogenic ...

We find that loss of SAGA complex KAT activity in MYCN-amplified neuroblastoma, through modulation of TADA2B, leads to a rapid and global loss ...

Role of the SAGA co-activator complex in transcription during cell ...

SAGA is a coactivator complex with histone acetyl transferase activity, deubiquitinase activity, and can bind the TATA-binding protein, TBP.

QuickGO::Term GO:0000124

GO:0000124 JSON. SAGA complex. Cellular Component. Definition (GO:0000124 GONUTS page). A SAGA-type histone acetyltransferase complex that deubiquitinates ...

Spt-Ada-Gcn5 acetyltransferase - Wikipedia

Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a multicomponent regulator of acetylation. [1] It has been found that this complex is highly conserved between ...

Structure of the human SAGA coactivator complex - bioRxiv

Our 2.9 Å structure of human SAGA reveals intertwined functional modules flexibly connected to a core that distinctively integrates mammalian ...

Architecture of the multi‐functional SAGA complex and ... - FEBS Press

Architecture of the SAGA-TBP complex. (A) SAGA subunits are organized into the Tra1-lobe and the main lobe. The main lobe is divided into two ...

Spt20, a Structural Subunit of the SAGA Complex, Regulates ...

The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex is a well-known transcriptional coactivator that is highly conserved in all eukaryotes (22, 23). It plays ...

Targeting the SAGA and ATAC Transcriptional Coactivator ...

GCN5 was defined in the late 1990s as a component of the Spt-Ada-Gcn5-Acetyl transferase (SAGA) complex in (i) yeast and (ii) related TFTC/STAGA complexes in ...

Composition of the SAGA complex in plants and its role in ... - Frontiers

In this review, the composition of the SAGA complex in plants is described and its role in gene expression regulation under stress conditions summarized.

Understanding the Role of the Saga Complex in Gene Expression ...

One complex that plays an important role in determining expression heterogeneity is the transcriptional co-activator Spt-Ada-Gcn5-acetyltransferase (SAGA).