The Surprising SAGA of a 20|Part Molecular Machine

The Surprising SAGA of a 20-Part Molecular Machine - HHMI

Howard Hughes Medical Institute (HHMI) Investigator Eva Nogales and her team have constructed a detailed 3D structure of human SAGA, ...

Quantifoil on LinkedIn: #cryoem #structuralbiology

For the first time, researchers have constructed a detailed 3D structure of human SAGA, a 20-piece molecular machine crucial to human life. The structure could ...

The SAGA coactivator complex acts on the whole transcribed ...

discovered that SAGA acetylates the promoters and deubiquitinates the transcribed region of all expressed genes. SAGA also plays a critical role for RNA ...

UPS writes a new saga of SAGA - ScienceDirect.com

The evolutionarily conserved SAGA was initially discovered as a HAT (20). ... Voges D, Zwick IP, Baumeister W (1999) The 26S proteasome: a molecular machine ...

HHMI Selects 20 International Student Research Fellows

Related News & Stories. Human SAGA. The Surprising SAGA of a 20-Part Molecular Machine. Nov 22, 2021.

The Tightly Controlled Deubiquitination Activity of the Human SAGA ...

... (20). In human cells, the SAGA ... Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.

Multifaceted activities of the plant SAGA complex - ScienceDirect.com

SAGA core module subunits TAF5 and TAF6 are required for viability in Arabidopsis [19,20], but it should be noted that, like ADA2 and GCN5, these two proteins ...

The molecular mechanisms underlying ... Inactivation of Supt20h had milder effects on SAGA subunit composition with core SAGA complexes still assembling.

SUPT3H-less SAGA coactivator can assemble and function without ...

The SAGA complex (Spt-Ada-Gcn5 Acetyltransferase) is an evolutionary conserved, multifunctional co-activator composed of about 18–20 subunits (3 ...

The SAGA complex, together with transcription factors and the ...

Molecular Biology of the CellVol. 28, No. 20 ArticlesFull Access. The SAGA complex, together with transcription factors and the endocytic ...

Molecular Biology of Gene Regulation: Transcription Factors - iBiology

00:39:36.20 So these are just two examples of sort of what we're learning about, 00:39:41.21 the continuing saga of how transcriptional machinery evolved and ...

Protein complexes and functional modules in molecular networks

A protein complex is a molecular machine that consists of several proteins (nucleic acids and other molecules) that bind each other at the same place and ...

Two roles for the yeast transcription coactivator SAGA and a set of ...

In addition to performing chromatin modifications, SAGA was recently shown to function as a TBP-DNA loading factor, mediated in part via TFIIA ...

The Nitrosamine “Saga”: Lessons Learned from Five Years of Scrutiny

(18) NDSRIs from drug–nitrite interactions (19,20) can contribute to the overall endogenous formation, but the more continual exposure stems ...

SAGA Is a General Cofactor for RNA Polymerase II Transcription

We find that SAGA maps to the UAS elements of most genes, overlapping with Mediator binding and irrespective of previous designations of SAGA- ...

SAGA and a novel Drosophila export complex anchor efficient ...

We have investigated the importance of the nuclear positioning of a gene, its transcription and the consequent export of the nascent mRNA. We show that E(y)2 is ...

Architecture of the Saccharomyces cerevisiae SAGA transcription ...

... molecular interactions of SAGA with transcription regulators and components of the transcription machinery. ... SAGA complex in 20 μl total ...

X-Men 97 is part of the Multiverse Saga : r/MarvelStudiosSpoilers

Kang is definitely going to be defeated by a Pepsi vending machine. Upvote

a symphony of transcription factors for gene control

Thus, it appears that we have unveiled the molecular machinery that could operate at a more species-specific or evolutionarily spe- cialized level. The ...

Transcription saga tells developmental stories | Development

A major goal of the meeting was to promote synergistic interactions between molecular and developmental biologists with a common interest in the ...