The T cell immune response against SARS|CoV|2

The T cell immune response against SARS-CoV-2 - Nature

The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T ...

Current understanding of T cell immunity against SARS-CoV-2

As an important part of adaptive immunity, T cells are indispensable in the defense against pathogens including viruses. SARS-CoV-2 is a new ...

Defending against SARS-CoV-2: The T cell perspective - PMC - NCBI

SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-19 outcome and long-term memory. Impaired early T cell-driven ...

T Cell Responses to SARS-CoV-2 - Annual Reviews

A large body of evidence generated in the last two and a half years addresses the roles of T cells in SARS-CoV-2 infection and following vaccination. Infection ...

T cell immunity to SARS-CoV-2 - ScienceDirect.com

Collectively, the current human data indicate that early induction of functional SARS-CoV-2-specific T cells correlate with viral control and mild disease, ...

T cell response to SARS-CoV-2 infection in humans - PubMed Central

T cell memory and effector function has been demonstrated against multiple viral epitopes, and, cross-reactive T cell responses have been demonstrated in ...

T-cell immunity to SARS-CoV-2: what if the known best is ... - Frontiers

About 89%-93% of the people who are clinically infected with SARS-CoV-2 mount a CD4+ T-cell memory response against at least one viral structural protein during ...

Understanding T cell responses to COVID-19 is essential ... - Science

Durable T cell responses to SARS-CoV-2 antigens after infection or vaccination improve immune-mediated viral clearance.

Long COVID manifests with T cell dysregulation, inflammation and ...

T cells have important roles in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity and pathogenesis, yet relatively little is ...

T cell immunity to COVID-19 vaccines - Science

However, accumulating data suggest that T cell responses play an important role in vaccine protection against severe COVID-19 disease, ...

T-cell response to SARS-CoV-2: kinetic and quantitative aspects ...

Virtually, all SARS-CoV-2-infected symptomatic individuals positive for antibodies against Nucleoprotein (NP) or Spike possess a broad ...

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in ...

Using HLA class I and II predicted peptide “megapools,” circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in ∼70% and 100% of COVID-19 ...

SARS-CoV-2-specific antibody and T-cell responses 1 year after ...

Our findings show that robust antibody and T-cell immunity against SARS-CoV-2 is present in the majority of recovered patients 12 months after ...

SARS-CoV-2 T Cell Immunity Responses following Natural Infection ...

Several studies have revealed that T cells can provide protection against reinfection [3] with persistent immunologic memory following SARS-CoV- ...

B and T cell response to SARS-CoV-2 vaccination in health care ...

T cell immunity against SARS-CoV-2 surface and nucleocapsid peptides were studied using interferon-γ release assays and intracellular flow cytometry. Vaccine- ...

Rapid induction of antigen-specific CD4 + T cells is associated with ...

Integrated analysis revealed coordinated immune responses with distinct trajectories in SARS-CoV-2-naive and recovered individuals. Last, whereas booster ...

The T cell immune response against SARS-CoV-2. - Europe PMC

T cell responses develop early and correlate with protection but are relatively impaired in severe disease and are associated with intense activation and ...

T cell response against SARS-CoV-2 persists after one year in ...

In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection is characterized by major immune dysfunctions.

T cell response to intact SARS-CoV-2 includes coronavirus cross ...

The acquired immune response to SARS-CoV-2 can limit infection, as shown by protection from reinfection (1) and the efficacy of vaccines (2). While antibodies ...

Impaired SARS-CoV-2 specific T-cell response in patients ... - Frontiers

Important hallmarks of severe disease are misdirected immune responses with ongoing cytokine production, profound lymphopenia and skewed T-cell ...