The Use of Janus Kinase Inhibitors in Axial Spondyloarthritis

In this review, we examine the role of JAK–STAT signaling in the pathogenesis of axSpA and summarize the results from recent clinical trials of JAKi.

The Use of Janus Kinase Inhibitors in Axial Spondyloarthritis - PubMed

Current pharmacological treatments of axial spondyloarthritis (axSpA) are limited to non-steroidal anti-inflammatory drugs (NSAIDs) and ...

Rationale and concerns for using JAK inhibitors in axial ...

Axial Spondyloarthritis (AxSpA) is a chronic illness with limited treatment options. The role of Janus kinase (JAK) inhibition as a therapeutic ...

Efficacy and safety of Janus kinase inhibitors in axial spondyloarthritis

JAKi are approved for the treatment of axial spondyloarthritis. Caution needs to be used when prescribing JAKi in patients with cardiovascular ...

Janus Kinase Inhibitors: A New Tool for the Treatment of Axial ...

Keywords: Janus kinases; JAK inhibitors; axial spondyloarthritis ... The Use of Janus Kinase Inhibitors in Axial Spondyloarthritis: Current ...

JAK inhibitors - National Axial Spondyloarthritis Society

The National Institute for Health and Care Excellence (NICE) approved the use of the JAK inhibitor upadacitinib, also known by the brand name, Rinvoq, on 30 ...

Potential Efficacy of Janus Kinase Inhibitors in the Treatment of a ...

Tumor necrosis factor inhibitors are effective and recommended in treating patients with coexisting spondyloarthritis (SpA) and ulcerative ...

(PDF) The Use of Janus Kinase Inhibitors in Axial Spondyloarthritis

Janus kinase (JAK) and signal transducers and activators of transcription (STAT) are a group of intracellular kinases that play a role in the signaling pathway ...

Impact of Janus Kinase Inhibition on the Treatment of Axial ...

The IL-23/IL-17 pathway is highly important in the pathogenesis of SpA and is partly controlled by JAK (5, 6). Therefore, JAK inhibitors offer ...

Efficacy and safety of Janus kinase inhibitors in patients with ...

JAK inhibitors showed a satisfactory and promising efficacy in the treatment of active AS not only in mitigating disease activity, but also substantially ...

JAK Inhibitors: A New Treatment Option on the Horizon for ...

Biologic medications, including TNF inhibitors (TNFi) and interleukin-17 (IL-17) inhibitors, have changed the face of treatment for spondyloarthritis (SpA), ...

Experts weigh in on JAK inhibitors for ankylosing spondylitis

Janus kinase (JAK) inhibitors are the newest treatment for ankylosing spondylitis. Experts share their use, how they are different, and their safety.

Janus kinase inhibitors and tumour necrosis factor inhibitors show a ...

The safety and persistence of Janus kinase inhibitors (JAKi) and tumour necrosis factor inhibitors (TNFi) for the treatment of rheumatoid arthritis (RA), ...

Evidence Review of Upadacitinib for the Treatment of Axial ...

... the use of upadacitinib for the treatment of patients with axial spondyloarthritis. Janus kinase inhibitors may be preferable among patients ...

(PDF) Janus Kinase Inhibitors: A New Tool for the Treatment of Axial ...

Over 10 years ago, small synthetic molecules capable of blocking the activity of Janus kinases (JAK) were introduced in the therapy of ...

JAK Inhibitors for the Treatment of Axial Spondyloarthritis | MJR

Axial spondyloarthritis (axSpA) is a chronic disease characterized by inflammation and new bone formation that causes pain and results in functional ...

Pain in axial spondyloarthritis: role of the JAK/STAT pathway

Consistent with the mechanism of action of different JAK inhibitors, in vivo studies have shown that tofacitinib preferentially inhibits both JAK1 and JAK3 and ...

Janus kinase-targeting therapies in rheumatology - Nature

JAK inhibitors are an important class of tsDMARDs. The rationale underlying the use of these inhibitors is that JAKs have pivotal roles in ...

rationale for Janus kinase inhibitors for the treatment of ...

Janus kinases mediate cytokine signaling for many immune cell responses underlying the pathogenesis of spondyloarthritis. Janus kinase ...

Efficacy and safety of Janus kinase inhibitors in patients with ...

Therefore, additional targeted drugs are needed. Over the past decades, Janus kinases(JAK) inhibitors have been widely used in the treatment of autoinflammatory ...