The benefits and risks of escalation versus early highly effective ...

There is growing support for using early highly effective treatment as the initial therapeutic approach in relapsing-remitting multiple ...

This review defines the strategies of escalation and early highly effective treatment, outlines the pros and cons of each, and provides an analysis of both the ...

The benefits and risks of escalation versus early highly effective ...

Expert opinion: The combination of robust efficacy, ease of administration and established safety profile is unique to a new therapy in MS. Findings from the ...

Benefits of early highly effective versus escalation treatment ...

Escalation approaches are more risk averse in terms of side-effects, as they start with a first-line low-moderate efficacy DMTs with favourable risk profile. If ...

Benefits of early highly effective versus escalation treatment ...

Earlier use of ALE is more cost-effective than in later lines, even when aggravating the impact of its side-effects tenfold. Retreatment with CLA was more cost- ...

Escalation vs Early Aggressive Treatment in Multiple Sclerosis

... most benefit from early aggressive treatment over escalation therapy. ... In this article, Dr Zhang discusses the benefits and risks associated with escalation vs ...

Early highly effective versus escalation treatment approaches in ...

Treatment decisions in multiple sclerosis have become increasingly complex, and weighing the benefits versus the risks of several different therapies has become ...

Comparing Two Approaches to Treat Relapsing-Remitting ... - PCORI

This study is comparing the benefits and risks of starting treatment with an escalation approach versus an early highly effective treatment approach for ...

Treating Early Relapsing Multiple Sclerosis: Induction & Escalation ...

Aside from the risk-benefit profiles of DMTs and disease ... Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis.

Early highly effective versus escalation treatment approaches in ...

Clinical trials in patients with relapsing multiple sclerosis have focused on pairwise comparisons but the effectiveness of different treatment approaches has ...

Escalation or high-efficacy disease-modifying therapies in multiple ...

... effective than escalation in reducing the risk of reaching ... Effectiveness and safety of early high-efficacy versus escalation therapy in.

Escalation Versus Induction/High-Efficacy Treatment Strategies for ...

Early intervention with induction/high-efficacy disease-modifying therapy may have the best risk-benefit profile for patients with relapsing-remitting multiple ...

Benefits of early highly effective versus escalation treatment ...

Earlier use of ALE is more cost-effective than in later lines, even when aggravating the impact of its side-effects tenfold. Retreatment with ...

Escalation Versus Induction/High-Efficacy Treatment Strategies for ...

Early intervention with induction/high-efficacy disease-modifying therapy may have the best risk-benefit profile for patients with relapsing- ...

Highly Effective Therapy Versus Escalation Approaches in Early ...

76. Vollmer, B.L. ∙ Wolf, A.B. ∙ Sillau, S. ... Evolution of Disease Modifying Therapy Benefits and Risks: An Argument for De-escalation as a Treatment Paradigm ...

Escalating to medium‐ versus high‐efficacy disease modifying ...

potential of effective disease control against tolerability, risks ... ment escalation vs immediate initiation of highly effective treatment for.

Treatment Escalation vs Immediate Initiation of Highly Effective ...

... effective treatment while taking as little risk as possible. However, in cases with clinical or neuroradiologic signs of high disease ...

(PDF) Benefits of early highly effective versus escalation treatment ...

Earlier use of ALE is more cost-effective than in later lines, even when aggravating the impact of its side-effects tenfold. Retreatment with ...

Escalation vs. Early Intense Therapy in Multiple Sclerosis - MDPI

The “escalation strategy” consists of starting treatment with drugs of low side-effect profile and low efficacy, and “escalating” to drugs of higher efficacy— ...

Evolution of Disease Modifying Therapy Benefits and Risks - Frontiers

... effective DMT. Two trials are underway to further evaluate escalation and early high efficacy treatment—Effectiveness of earLy Intensive Vs. Escalation ...