The biology of YAP in programmed cell death

The biology of YAP in programmed cell death - PMC - NCBI

YAP can inhibit or induce different forms of PCD, including apoptosis, autophagy, ferroptosis and pyroptosis.

The biology of YAP in programmed cell death - Biomarker Research

YAP has been shown to be critical in regulating tumor progression. YAP activity can be regulated by many kinase cascade pathways and proteins.

The biology of YAP in programmed cell death - PubMed

In the last few decades, YAP has been shown to be critical in regulating tumor progression. YAP activity can be regulated by many kinase ...

The biology of YAP in programmed cell death - Biomarker Research

In the last few decades, YAP has been shown to be critical in regulating tumor progression. YAP activity can be regulated by many kinase cascade pathways ...

Role of YAP Signaling in Regulation of Programmed Cell Death and ...

A recent study showed that YAP plays a vital role in evasion of apoptosis by mediating cancer cell dormancy, which involves recruitment of the EMT ...

The roles of Hippo/YAP signaling pathway in physical therapy - Nature

Moreover, YAP inhibition increased high shear stress-induced cell apoptosis, suggesting that YAP might promote tumor metastasis by inducing EMT ...

The Biology of YAP/TAZ: Hippo Signaling and Beyond

In tumors, YAP/TAZ can reprogram cancer cells into cancer stem cells and incite tumor initiation, progression and metastasis. As such, YAP/TAZ are appealing ...

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo ...

apoptosis regulated by Hippo pathways under different cell density and other biological contexts. Under low cell density with limited cell–cell contact, Hippo ...

Expected and unexpected effects after systemic inhibition of Hippo ...

In those cancers, hyperactivation of YAP and TAZ induces a transcriptional program that includes target genes involved in cell cycle progression ...

Role of the YAP/TAZ-TEAD Transcriptional Complex in the ... - MDPI

Indeed, YAP has been shown to play a key role in inhibiting apoptosis in cancer cells [24,25,26,27], although a pro-apoptotic function of YAP ...

YAP mediates apoptosis through failed integrin adhesion ...

Whereas cell proliferation on stiff matrices, wherein Yes-associated protein (YAP) plays a pivotal role, is well documented, activation of apoptosis in response ...

Role of YAP/TAZ in Cell Lineage Fate Determination and ... - Frontiers

The penultimate effectors of the Hippo signaling pathways YAP and TAZ, are transcriptional co-activator proteins that play key roles in many diverse biological ...

The Hippo Signaling Pathway Coordinately Regulates Cell ...

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP ... cell death ( ...

Context-dependent roles of YAP/TAZ in stem cell fates and cancer

differentiation and cancer cell survival vs. apoptosis. In this review, we present an overview of the multiple context-dependent functions of ...

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 ...

That is, a high level of YAP/TAZ protects cells from apoptosis but promotes ferroptosis. ... Ferroptosis: a regulated cell death nexus linking metabolism, redox ...

Reciprocal Crosstalk Between YAP1/Hippo Pathway and the p53 ...

Inactivation of LATS1/2 kinase leads to a transient YAP-mediated hypertranscription and proliferation of neural progenitor cells during brain ...

The Ambivalent Function of YAP in Apoptosis and Cancer - MDPI

Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews ...

The biology of YAP/TAZ: hippo signaling and beyond. - Europe PMC

YAP and TAZ activity is key for the growth of whole organs, for amplification of tissue-specific progenitor cells during tissue renewal and regeneration, and ...

Simultaneous knockdown of YAP and TAZ increases apoptosis of ...

Knockdown of YAP or TAZ does not affect the survival of HCC cells in normoxic and hypoxic microenvironment. In addition, the rate of apoptosis by knockdown or ...

YAP activates the Hippo pathway in a negative feedback loop

Request PDF | YAP activates the Hippo pathway in a negative feedback loop | Cell death and differentiation is a monthly research journal focused on the ...