The covalent NLRP3|inflammasome inhibitor Oridonin relieves ...

The covalent NLRP3-inflammasome inhibitor Oridonin ... - PubMed

The covalent NLRP3-inflammasome inhibitor Oridonin reduces myocardial fibrosis and preserves cardiac function in a mouse MI model, ...

The covalent NLRP3-inflammasome inhibitor Oridonin relieves ...

Oridonin is a newly reported NLRP3 inhibitor with strong anti-inflammatory activity. We hypothesized that the covalent NLRP3 inhibitor Oridonin could reduce IL- ...

Oridonin is a covalent NLRP3 inhibitor with strong anti ... - Nature

Here, we show that Ori is a specific and covalent inhibitor for NLRP3 inflammasome. Ori forms a covalent bond with the cysteine 279 of NLRP3 in ...

The covalent NLRP3-inflammasome inhibitor Oridonin relieves ...

In the mouse MI model, Oridonin inhibits myocardial fibrosis, reduces myocardial infarct size, and improves cardiac function in mice after MI. Animal and cell ...

The covalent NLRP3-inflammasome inhibitor Oridonin relieves ...

Download Citation | The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in ...

The covalent NLRP3-inflammasome inhibitor Oridonin relieves ...

Oridonin, as well as MCC950 and CY-09, inhibits the NLRP3 inflammasome response.•Oridonin, found in traditional Chinese medicine, shows anti-inflammatory ...

Oridonin supplementation attenuates atherosclerosis via NLRP-3 ...

Atherosclerosis has a major impact on the pathogenesis of cardiovascular diseases. Oridonin has been shown to exclusively inhibit the NLRP3 inflammasome without ...

The covalent NLRP3-inflammasome inhibitor Oridonin ... - Altmetric

The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice · International ...

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

The link between NLRP3 inflammasome dysregulation and a variety of human diseases has suggested the value of NLRP3 inhibitors for therapeutic interventions.

The covalent NLRP3-inflammasome inhibitor Oridonin relieves ...

The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice · Ri-Feng Gao · Xiao ...

Interrogating direct NLRP3 engagement and functional ... - Cell Press

We provide quantitative comparisons between inhibitors and establish rank order potency in cells. The majority of putative NLRP3 inhibitors ...

Natural Products that Target the NLRP3 Inflammasome to Treat ...

Oridonin (3), andrographolide (4), and triptolide (5) are three diterpenoids exhibiting an antifibrotic effect via inhibiting NLRP3 inflammasome activation. In ...

Oridonin is a covalent NLRP3 inhibitor with strong anti ...

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, ...

Pharmacological Inhibition of the NLRP3 Inflammasome: Structure ...

Inhibition of the NLRP3 inflammasome with MCC950 partially reversed the liver inflammation and liver scarring, particularly in obese diabetic ...

The glycolytic metabolite methylglyoxal covalently inactivates the ...

Here, we show that MGO acts similarly to the reactive metabolites fumarate and itaconate, capable of both activating NRF2 and inhibiting the NLRP3 inflammasome.

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug ... - MDPI

This binding prevents the interaction between NLRP3 and NEK7, which is essential for NLRP3 inflammasome assembly and activation [176]. Recently, oridonin has ...

Inhibitors of the NLRP3 inflammasome pathway as promising ...

When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro‑caspase‑1, resulting in inflammatory cytokine maturation ...

Oridonin is a covalent NLRP3 inhibitor with strong anti ... - OUCI

NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of ...

(PDF) Oridonin is a covalent NLRP3 inhibitor with strong anti ...

Here, we show that Ori is a specific and covalent inhibitor for NLRP3 inflammasome. Ori forms a covalent bond with the cysteine 279 of NLRP3 in ...