The effect of cofactors and vitamins on homocysteine and ...

The effect of cofactors and vitamins on homocysteine and methylmalonic acid metabolism in health and disease · Summary · Scientific abstract.

Scientific abstract. Many world-wide studies have shown a moderate increase of homocysteine to be a risk factor for vascular disease. Homocysteine arises from ...

Association between vitamin B group supplementation with changes ...

contributed to the reduction of plasma homocysteine levels have been investigated. Not only folic acid but also vitamin B12 is an essential cofactor for the ...

Methylation and Homocysteine: A Brief Overview - Food for the Brain

The complex metabolism of homocysteine within the body is highly dependent on vitamin derived cofactors. Deficiencies in vitamin B12, folic acid and vitamin ...

The metabolism and significance of homocysteine in nutrition and ...

Studies on supplementation with folate, vitamins B6 and B12 have shown reduction in Hcy levels but concomitant reduction in certain associated ...

The effect of vitamin B supplementation on homocysteine ...

These data support the hypothesis that AEDs play a major role in hyperhomocysteinemia development in patients with epilepsy. Adding folate and vitamin B12 to ...

Homocysteine Levels and Cardiovascular Disease - AAFP

Deficiency of folic acid, or vitamin B6 or vitamin B12 cofactors can lead to excess homocysteine levels. ... The major potential side effect of ...

Hyperhomocysteinemia - an overview | ScienceDirect Topics

Because elevated plasma homocysteine levels are associated with low levels of the enzymatic cofactors folic acid, vitamin B6, and vitamin B12, vitamin ...

Knowledge on rare diseases and orphan drugs - Orphanet

The effect of cofactors and vitamins on homocysteine and methylmalonic acid metabolism in health and disease (1). Type of research project: Animal model ...

Vitamins as Homocysteine-Lowering Agents - The Journal of Nutrition

Folic acid doses of <1 mg/d may be effective. Supplementation with a combination of folic acid and cyanocobalamin will secure full homocysteine-lowering effect ...

Role of homocysteine and vitamin B in bone metabolism - Elsevier

Folate (vitamin B9), and vitamins B12 (cobalamin), B6 (pyridoxine) and B2 (riboflavin) play a key role in the metabolism of homocysteine7,8; consequently, ...

Homocysteine, vitamin B12, folates, vitamin B6, choline, betaine

Methionine is converted to S-adenosylmethionine (SAM), which functions as a universal donor of methyl groups. The de methylation of SAM results in the formation ...

Vitamin B12 - Linus Pauling Institute

Figure 1. Vitamin B12 and Homocysteine Metabolism. Methionine synthase is a vitamin B12-. Cofactor for L-methylmalonyl-coenzyme A mutase. 5- ...

The Imbalance of Homocysteine, Vitamin B12 and Folic Acid ... - MDPI

The contribution of homocysteine (Hcy) to the development of neurodegenerative disorders has been increasingly recognized. Vitamins involved in Hcy metabolism, ...

Homocysteine—a retrospective and prospective appraisal - Frontiers

Supplements of folic acid and vitamin B12 are often prescribed to maximize residual MTHFR activity and promote methionine synthase activity. As the product of ...

B vitamins and homocysteine as determinants of bone health: A ...

Folate and vitamin B12 play a vital role in the methylation pathway of methionine synthesis; therefore, their deficiencies cause megaloblastic ...

Homocysteine and levodopa - Neurology.org

One important determinant of serum homocysteine is the level of serum B vitamins (especially folate); vitamin B12 and folate supplementation decreases ...

Genetics of homocysteine metabolism and associated disorders

Therefore, plasma Hcy levels are determined by several factors such as the cofactors vitamin B12, vitamin B6 and folic acid and enzymes involved in methionine ...

Vitamins as Homocysteine-Lowering Agents

the cofactors for homocysteine metabolism, pyridoxal. 5-phosphate ... wk) had no effect on plasma homocysteine concentra tion in 16 healthy subjects ...

Homocysteine and Neurologic Disease - JAMA Network

This enzyme requires vitamin B12 as a cofactor and uses N5-methyltetrahydrofolate as the methyl donor. The remethylation process is primarily responsible for ...