The emerging role of one|carbon metabolism in T cells

The emerging role of one-carbon metabolism in T cells - PubMed

One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, ...

The emerging role of one-carbon metabolism in T cells - ScienceDirect

In this review, we highlight key components and summarize critical steps of 1CM and discuss how they contribute to normal and pathological T cell functions.

The emerging role of one-carbon metabolism in T cells

In: Current Opinion in Biotechnology. 2021 ; Vol. 68. pp. 193-201. ... The emerging role of one-carbon metabolism in T cells. / Kurniawan, Henry; Kobayashi, ...

(PDF) The emerging role of one-carbon metabolism in T cells

PDF | One-carbon metabolism (1CM) supports multiple biological functions, providing 1C units for nucleotide synthesis, epigenetic maintenance, and redox.

The emerging role of one-carbon metabolism in T cells

Cite this ... Kurniawan, Henry ; Kobayashi, Takumi ; Brenner, Dirk. / The emerging role of one-carbon metabolism in T cells. In: Current Opinion in Biotechnology.

One carbon (metabolism) to rule T cell identity - Nature

A preprint by Sugiura et al. looks at the role of one-carbon metabolism during T cell activation, with a focus on autoimmune disease, ...

The emerging role of one-carbon metabolism in T cells – Fingerprint

Dive into the research topics of 'The emerging role of one-carbon metabolism in T cells'. Together they form a unique fingerprint. Sort by; Weight ...

Targeting one‐carbon metabolism for cancer immunotherapy - PMC

1C metabolism maintains biosynthesis and metabolic regulation to preserve the function of immune cells. Reports have shown that 1C metabolism ...

Metabolism and epigenetics at the heart of T cell function

Alterations in metabolite concentrations can influence the epigenetic landscape in T cells, thereby affecting T cell differentiation, ...

Extracellular acidosis restricts one-carbon metabolism and ... - Nature

Our findings not only reveal an unexpected capacity of extracellular acidosis to maintain the stem-like properties of T cells, but also advance ...

Defective respiration and one-carbon metabolism contribute ... - PNAS

Rewiring of intracellular metabolism is key for T cell activation and effector functions, but the metabolic changes in T cells during aging are ...

The emerging role of one-carbon metabolism in T cells - OUCI

Publications that cite this publication · Metabolic and epigenetic orchestration of (CAR) T cell fate and function · The Role of Microbiota-Derived Vitamins in ...

Advances in reprogramming of energy metabolism in tumor T cells

Glutamine metabolism supplies carbon and nitrogen necessary for the synthesis of amino acids, nucleic acids, and lipids. The lack of glutamine inhibits T cell ...

T cell metabolism drives immunity | Journal of Experimental Medicine

Given that mitochondrial ROS and HIF-1α activity are important for the metabolic reprogramming of naive T cells after activation, it is ...

Targeting memory T cell metabolism to improve immunity - JCI

Our group showed that CD28 costimulation during T cell activation provides important signals to the mitochondria, transiently promoting the ...

Review - One-Carbon Metabolism in Health and Disease - Cell Press

More generally, the lack of nuclear-specific enzymes has hindered efforts to assign function to nuclear folate metabolism. Sources of 1C Units.

Fundamentals of T Cell Metabolism and Strategies to Enhance ...

(B) Upon T cell stimulation T cells undergo protein and transcriptional changes in metabolism that allow the sustained activity of glycolysis and other amino ...

The tumor microenvironment as a metabolic barrier to effector T cells ...

The mitochondria of T lymphocytes also undergo significant proteomic changes that favor one-carbon metabolism critical for nucleotide synthesis, ...

Amino acid metabolism in immune cells: essential regulators of the ...

Although there is no direct evidence demonstrating a role of BCAA metabolism in anti-tumor immunity, these observations indicate that activation ...

Immunogenetic Metabolomics Reveals Key Enzymes That Modulate ...

Deeper understanding of CAR T-cell metabolism is needed to optimize such therapeutics. The authors identify ADA as a regulator of T-cell metabolism whose.