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The emerging roles of SUMOylation in the tumor microenvironment ...


The emerging roles of SUMOylation in the tumor microenvironment ...

Cancer cells as well as stroma cells can not only obtain adaption to the TME but also sculpt their microenvironment through a series of ...

The emerging roles of SUMOylation in the tumor microenvironment ...

The purpose of this review is to explore the role that SUMOylation plays in the TME formation and reprogramming, emphasize the importance of targeting ...

The emerging roles of SUMOylation in the tumor microenvironment ...

Cancer. SUMO enzyme(s). Substrate. Biological mechanisms and functions. Refs. GBM. UBC9. CRMP2. Promote cancer cell proliferation. [16]. SUMO1.

The emerging roles of SUMOylation in the tumor microenvironment ...

Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment ...

The emerging roles of SUMOylation in the tumor ... - OpenAlex

The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications. Work. HTML PDF. Year: 2023. Type: review. Abstract: Tumor ...

(PDF) The emerging roles of SUMOylation in the tumor ... - Typeset.io

Cancer cells as well as stroma cells can not only obtain adaption to the TME but also sculpt their microenvironment through a series of signaling pathways. The ...

Distinctive tumorigenic significance and innovative oncology targets ...

The SUMOylation cascade frequently emerges as a key player in tumor initiation, progression, and response to therapies. In most cases, SUMOylation exerts an ...

SUMOylation patterns and signature characterize the tumor ...

However, the precise role of SUMOylation in lung adenocarcinoma (LUAD), especially in the tumor immune microenvironment, is not yet clear. Methods: We ...

Inhibition of SUMOylation Induces Adaptive Antitumor Immunity ...

SUMO modification adds a new docking site to target proteins and thus enables signaling and/or modifies protein complex formation through the ...

The emerging roles of SUMOylation in the tumor microenvironment ...

Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor.

Ubiquitination and SUMOylation in the chronic inflammatory tumor ...

SUMOylation is also known to participate in tumorigenesis via conjugating and altering the functions of protein targets. However, there are conflicting reports ...

Leveraging SUMOylation To Regulate Immune Response

Of equal importance, there is compelling evidence that SUMOylation facilitates cancer progression by modifying the tumor microenvironment and disrupting normal ...

SUMOylation Pattern Predicts Prognosis and Indicates Tumor ...

Background: SUMOylation is an important component of post-translational protein modifications (PTMs), and bladder cancer (BCa) is the ninth most common cancer ...

The Function of SUMOylation and Its Role in the Development of ...

SUMOylation is a key point in the dysfunction of tumor suppressor proteins and oncoproteins as well as some cancer-related pathways that are ...

Targeting SUMO Signaling to Wrestle Cancer - Cell Press

In this review, we discuss the important role SUMO may play in cancer and how to target SUMO signaling. Recently developed small molecule ...

The Role of Protein SUMOylation in Human Hepatocellular Carcinoma

CPAP can interact with HBx to provide a microenvironment for the development of cancer cells. Inhibition of CPAP can inhibit the proliferation ...

Dissecting multiple roles of SUMOylation in prostate cancer

The dual opposing roles of SUMOylation in prostate cancer (PCa). · The aberrant expression of SUMO machinery components and deregulation of ...

B cell receptor-induced protein dynamics and the emerging role of ...

Interestingly, our differential expression analysis identified dynamic responses in various proteins previously not linked to early B cell activation. We ...

The post-translational modification, SUMOylation, and cancer ...

SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis.

The emerging roles of SUMOylation in the tumor microenvironment ...

Besides, 46 cases of colon cancer were investigated, showing that patients who exhibited high expression of. SUMO1 and SUMOylated P53 were more likely to expe-.