The genomic definition of high|risk myeloma

What Is Genomic High-Risk Myeloma? - MDPI

... genomic studies into clinical trials will aid in defining the genomic high-risk landscape of multiple myeloma, which in turn can be transferred to ...

The genomic definition of high-risk myeloma - VJHemOnc

Jill Corre, PhD, The Cancer University Institute of Toulouse Oncopole, Toulouse, France, discusses the genomic markers of high-risk myeloma ...

The genomic definition of high-risk myeloma - YouTube

Jill Corre, PhD, The Cancer University Institute of Toulouse Oncopole, Toulouse, France, discusses the genomic markers of high-risk myeloma ...

The genomic profiling of high-risk smoldering myeloma patients ...

In 2014, the International Myeloma Working Group (IMWG) updated the definition of MM [4], re-classifying ultra-high risk SMM patients (80% ...

Definers and drivers of functional high-risk multiple myeloma

In a subset of patients with MM, adverse disease biology only becomes evident after the failure of first-line therapy. We define this entity as functional high- ...

The genomic features associated with high-risk multiple myeloma

Advances in genomic studies provide an important tool to segment MM into individual risk strata based on the idea that acquired genetic events ...

The genomic definition of ultra-high-risk multiple myeloma

Jill Corre, PhD, The Cancer University Institute of Toulouse Oncopole, Toulouse, France, discusses the genomic criteria for defining ...

Genomic characterization of functional high-risk multiple myeloma ...

Multiple myeloma (MM) patients with suboptimal response to induction therapy or early relapse, classified as the functional high-risk (FHR) ...

The genomic definition of ultra-high-risk multiple myeloma - YouTube

Jill Corre, PhD, The Cancer University Institute of Toulouse Oncopole, Toulouse, France, discusses the genomic criteria for defining ...

What Is Genomic High-Risk Myeloma? - IU Indianapolis ScholarWorks

... genomic studies into clinical trials will aid in defining the genomic high-risk landscape of multiple myeloma, which in turn can be transferred to ...

Reaching Consensus on Defining, Treating High-Risk Myeloma

A new consensus definition for high-risk myeloma patients and promising results from trials dedicated to their care may offer a paradigm shift in treatment.

IMS 2024: News for High-Risk Multiple Myeloma - HealthTree

How Is the Definition of High-Risk Myeloma Evolving? · Myeloma with at least 20% of cells showing the genetic characteristic of deletion 17p.

High-resolution genomic profiles define distinct clinico-pathogenetic ...

To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number ...

Risk Stratification and Targets in Multiple Myeloma: From Genomics ...

No single gene mutation was observed. The most frequently mutated genes are the KRAS and NRAS genes (approximately 25% and 20% of patients, respectively), ...

A validated gene expression model of high-risk multiple myeloma is ...

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple ...

Genomic analysis of high-risk smoldering multiple myeloma

15,16 HR-SMM were defined by the presence of more than 10% PCs in BM and an MC of IgG more than 3 g/dL, IgA more than 2 g/dL, or Bence Jones proteinuria more ...

Areas of research currently being explored for ultra-high-risk ...

The genomic definition of ultra-high-risk multiple myeloma. Jill Corre • 24 May 2024 · 1:38. The genomic definition of high-risk myeloma. Jill ...

Genomic Classification and Individualized Prognosis in Multiple ...

To build a model predicting individualized risk in NDMM (IRMMa), we integrated clinical, genomic, and treatment variables. To correct for time- ...

Treatment of multiple myeloma with high-risk cytogenetics

The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic ...

The genomics of high-risk myeloma - YouTube

Nikhil Munshi, MD, Dana-Farber Cancer Institute, Boston, MA, discusses the genomics of high-risk myeloma. Specifically, the staging of ...