The genomic landscape of pediatric and young adult T|lineage ...

The genomic landscape of pediatric and young adult T-lineage ...

Using integrated genomic analysis of 264 T-ALL cases, we identified 106 putative driver genes, half of which had not previously been described in childhood T- ...

The genomic landscape of pediatric and young adult T-lineage ...

Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, ...

THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT ...

Genetic alterations activating NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors are hallmarks ...

The genomic landscape of pediatric and young adult T-lineage ...

This genomic landscape provides a logical framework for the development of faithful genetic models and new therapeutic approaches.

The genomic landscape of pediatric and young adult T-lineage ...

Charles Mullighan, Stephen Hunger, Jinghui Zhang and colleagues report a genomic analysis of 264 pediatric and young adult T-lineage acute lymphoblastic ...

The genomic landscape of pediatric and young adult T-lineage ...

Abstract. Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor ...

the genomic landscape of pediatric and young adult t-lineage acute ...

Using integrated genomic analysis of 264 T-ALL cases, 106 putative driver genes are identified and new mechanisms of coding and noncoding alteration are ...

The genomic landscape of pediatric and young adult T-lineage ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Author List. Liu Y, Easton J, Shao Y, Maciaszek J, Wang Z ...

The genomic landscape of pediatric and young adult T-lineage ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. · Read more · Loading Visualization · Visualization Code · About.

The genomic landscape of pediatric and young adult T-lineage ...

Abstract: Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor ...

The genomic landscape of pediatric and young adult T-lineage ...

Request PDF | The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia | Genetic alterations that activate NOTCH1 signaling ...

The genomic landscape of pediatric acute lymphoblastic leukemia ...

Nevertheless, outcomes of older adolescents and young adults with ALL still lag behind those of their younger counterparts despite pediatric-inspired ...

The genomic landscape of pediatric and young adult T-lineage ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Yu Liu, John Easton, Ying Shao, Jamie Maciaszek, Zhaoming Wang ...

The genomic landscape of teenage and young adult T‐cell acute ...

All genetic aberrations in TYA T-ALL occurred with an incidence similar or intermediate to that reported in the pediatric and adult literature, ...

The genomic landscape of teenage and young adult T‐cell acute ...

PDF | Background Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute.

Researchers Map Genomic Landscape of ALL

... landscape for acute lymphoblastic leukemia (ALL), the most common pediatric cancer. ... young adults with newly diagnosed B-ALL or T-ALL. The ...

The landscape of genomic alterations across childhood cancers

We have carried out a broad exploration of cancers in children, adolescents, and young adults, by incorporating small mutations and copy-number ...

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Methods: We studied 2789 children, adolescents and young adults (AYA) with newly diagnosed B-ALL (n=2,322 cases) or T-ALL (n=467) treated on ...

The genomic landscape of teenage and young adult T

Deep sequencing and. SNP array analyses of pediatric T- cell acute lymphoblastic leuke- mia reveal NOTCH1 mutations in minor subclones and a ...

Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic ...

Recent technologic advances have enabled detailed characterization of the genomic landscape of childhood ... young adults and older adults differ in their ...