The identification of dual protective agents against cisplatin|induced ...

The identification of dual protective agents against cisplatin-induced ...

Cisplatin is a highly effective anticancer agent that primarily functions through covalent-binding to purine bases, resulting in DNA crosslinks, activation of ...

The identification of dual protective agents against cisplatin-induced ...

Dose-limiting toxicities for cisplatin administration, including ototoxicity and nephrotoxicity, impact the clinical utility of this ...

Figures and data in The identification of dual protective agents ...

The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model.

The identification of dual protective agents against cisplatin-induced ...

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. by Jaime N Wertman, Nicole Melong, ...

(PDF) The identification of dual protective agents against cisplatin ...

The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model. July 2020; eLife 9. 9. DOI:10.7554 ...

Peer review in The identification of dual protective agents against ...

The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model. Jaime N Wertman · Nicole Melong ...

The identification of dual protective agents against cisplatin-induced ...

Using a two-pronged drug screen employing the zebrafish lateral line as an in vivo readout for ototoxicity and kidney cell-based nephrotoxicity ...

The identification of dual protective agents against cisplatin-induced ...

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model · Abstract · List of references.

Advances in Understanding Cisplatin-Induced Toxicity

The cisplatin-DNA adducts cause bending and unwinding of the DNA double helix, leading to conformational changes in the local DNA structure ( ...

[PDF] An Integrated In Silico and In Vivo Approach to Identify ...

... Identify Protective Effects of Palonosetron in Cisplatin ... The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using ...

Direct targeting of mitochondria by cisplatin leads to cytotoxicity in ...

32. Wertman, J.N. ∙ Melong, N. ∙ Stoyek, M.R. ... The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the ...

Overview of cisplatin-induced neurotoxicity and ototoxicity, and the ...

Based on the above-described mechanisms of toxicity, the neuroprotection studies have targeted on cisplatin accumulation; DNA-Pt adducts formation, oxidative ...

Progress in the Development of Preventative Drugs for Cisplatin ...

All the compounds studied in clinical trials, except for aspirin and lipoic acid, have been proved to provide some protection against cisplatin- ...

Evaluating protective and therapeutic effects of alpha-lipoic acid on ...

Treatment with cisplatin only decreased cell viability to 40%. However, with pre- or post-treatment of ALA, cell viability was significantly ...

Citations to ORC-13661 protects sensory hair cells from ... - JCI Insight

The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model. JN Wertman, N Melong, MR Stoyek, O ...

Cisplatin-Induced Ototoxicity: A Concise Review of the Burden ...

Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ...

Current Strategies to Combat Cisplatin-Induced Ototoxicity - Frontiers

The focus of this review is to identify candidate agents as novel molecular targets, drug administration routes, delivery systems, and dosage schedules. Animal ...

Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection ...

Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that ...

Tuning the metabolism of the anticancer drug cisplatin with ...

Tuning the metabolism of the anticancer drug cisplatin with chemoprotective agents ... The identification of dual protective agents against cisplatin-induced oto- ...

Effect of protective agents against cisplatin ototoxicity | Request PDF

... Cisplatin's impact on antioxidant enzyme levels further exacerbates its ototoxic effects, as it directly reduces the levels of antioxidants, such as SOD, ...