The key players of parthanatos

The key players of parthanatos: opportunities for targeting ... - PubMed

Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, ...

The key players of parthanatos: opportunities for targeting multiple ...

Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, such as Parkinson's ...

The key players of parthanatos: opportunities for targeting multiple ...

Xianlu Zeng; Jinmin Gao; Xueqing Ba; Ruoxi Wang. Funders. National Natural Science Foundation of China; Postdoctoral Research Foundation of ...

Parthanatos: Mechanisms, modulation, and therapeutic prospects in ...

The primary route of cell death in these diseases is Parthanatos, a cell death signaling pathway that is triggered by pathological stressors. Parthanatos, or ...

The key players of parthanatos: opportunities for targeting multiple ...

Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases, particularly neurodegenerative disorders, ...

Exploring the role of parthanatos in CNS injury - ScienceDirect.com

Parthanatos is a poly (ADP-ribose) polymerase 1 (PARP-1)-dependent form of programmed cell death that is partly responsible for neural cell death.

Parthanatos: mitochondrial‐linked mechanisms and therapeutic ...

This review describes the multistep course of parthanatos and its dependence on PAR signalling and nuclear AIF translocation.

The key players of parthanatos: opportunities for targeting multiple ...

The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis-article.

Parthanatos initiated by ROS-induced DNA damage is involved in ...

Our work verifies a previously unexplored role for parthanatos in intestinal epithelial damage during NEC and suggests that inhibition of parthanatos may serve ...

Parthanatos: mitochondrial‐linked mechanisms and therapeutic ...

The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis · Medicine. Cellular and Molecular ...

Targeting Parthanatos in Ischemic Stroke - Frontiers

PARP's instigation of cell death involves release of apoptosis-inducing factor (AIF) from a mobile pool in the outer mitochondrial membrane (30– ...

Parthanatos - Wikipedia

Parthanatos (derived from the Greek Θάνατος, "Death") is a form of programmed cell death that is distinct from other cell death processes such as necrosis and ...

Molecular Mechanisms of Parthanatos and Its Role in Diverse ...

The mechanisms of parthanatos mainly include DNA damage, PARP1 hyper-activation, PAR accumulation, NAD+ and ATP depletion, and AIF nucleus ...

Parthanatos type programmed cell death and septic patient mortality

3–8 Parthanatos (with PARP-1 activation, AIF translocation from mitochondria to the nucleus and DNA fragmentation) has been found in patients with infection by ...

Molecular mechanisms of cell death by parthanatos: More questions ...

Regulated cell death by a non-apoptotic pathway known as parthanatos is increasingly recognised as a central player in pathological processes.

Parthanatos in the pathogenesis of nervous system diseases

92 Parthanatos has been linked to cell death caused by oxidative stress after damage. In the presence of Mg 2+ in a pathological medium simulating metabolic ...

The Expression of Parthanatos Markers and miR-7 Mimic Protects ...

In the cytokine cascade, MIF is an upstream player that triggers and amplifies cytokine production by stimulating the production of ...

Parthanatos - British Pharmacological Society | Journals

In this review, we discuss the entire course and sequence of events of parthanatos and the key role of apoptosis- ... Players in parthanatos.

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting ...

Parthanatos is one of the major pathways of programmed cell death in ischemic stroke characterized by DNA damage, poly (ADP-ribose) ...

Parthanatos Antibody Sampler Kit #26768 - Cell Signaling Technology

Parthanatos is a form of regulated cell death that follows a multistep cascade and is triggered by the accumulation of poly (ADP-ribose) (PAR). When PAR ...