The mechanobiology of NK cells| 'Forcing NK to Sense' target cells

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

Natural killer (NK) cells are innate immune lymphocytes that recognize and kill cancer and infected cells, which makes them unique ...

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

We review recent advances in understanding how NK cells perceive and mechanotransduce biophysical cues.

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. Authors: Wong, Darren Chen Pei · Ding, Jeak Ling. Issue Date: Mar-2023. Publisher: Elsevier ...

The mechanobiology of NK cells - NUS Biological Sciences

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. Darren Chen Pei Wong a,*, Jeak Ling Dinga,b,* a Department of Biological ...

Mechanosensation and Mechanotransduction in Natural Killer Cells

NK/target cell interaction is regulated by adhesion molecules such as β1 and β2 integrins that play either a receptor or co-receptor role (7).

Natural Killer Cell Mechanosensing in Solid Tumors - MDPI

... cytotoxic immunological synapse on target cells [32,54]. ... Wong, D.C.P.; Ding, J.L. The Mechanobiology of NK Cells—“Forcing NK to Sense” Target ...

Development of NK cell-based cancer immunotherapies through ...

Notably, as NK cells can detect tumor cells through many activating endogenous receptors, even if the CAR target antigen is lost, cytotoxic ...

p35 is a Crucial Player in NK-cell Cytotoxicity and TGFβ-mediated ...

... detect significant levels of CDK5/p35 kinase activity in NK92 cells (Fig. ... The primary role of NK cells is cell-mediated cytotoxicity against aberrant target ...

Venetoclax acts as an immunometabolic modulator to potentiate ...

∙ Ding, J.L.. The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. Biochim. Biophys. Acta. Rev. Cancer. 2023; 1878, 188860. Crossref · Scopus (6).

Mechanosensation and Mechanotransduction in Natural Killer Cells

Natural killer (NK) cells are a main subset of innate lymphocytes that contribute to host immune protection against viruses and tumors by mediating target ...

The Molecular Mechanism of Natural Killer Cells Function and Its ...

NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells and control the cytolytic ...

An automated real-time microfluidic platform to probe single NK cell ...

We present a fully automated droplet-based microfluidic platform that allowed the real-time monitoring of effector-target cell interactions and killing.

Mechanosensation and Mechanotransduction in Natural Killer Cells

Actin represents the structural basis for NK cell immunological synapse (NKIS) and polarization of secretory apparatus. NK-target cell ...

Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2023, 1878 (2) ...

NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic ...

... mechanical tumor microenvironment: Cancer cell sensing, mechanobiology ... NK cell sensitivity for target cells is controlled by regulatory T cells. J ...

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. NK细胞的机械生物学——“强迫NK感知”靶细胞. 相关领域. 强迫（数学）机械生物学感应（电子）细胞 ...

NK cell education: Physiological and pathological influences

NK cells require integration of activating and inhibitory NK cell receptors to detect target cells and the balance of these NK cell inputs defines the ...

Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells

Here, we explore the mechanosensing of the third type of lymphocytes – Natural Killer (NK) cells, by showing that they modulate their immune ...

What Are Natural Killer Cells (NK Cells)? - Cleveland Clinic

If they detect signs a cell is harmful, they release deadly chemicals ... NK cells release perforin and granzymes to kill a target cell.

The mechanobiology of NK cells- 'Forcing NK to Sense' target cells.

NK细胞的力学生物学-“迫使NK感知”目标细胞。 The mechanobiology of NK cells- 'Forcing NK to Sense' target cells. Original text. 发表日期：2023 Feb 13. 作者 ...