The molecular mechanisms of the Mre11/Rad50 DNA repair complex

The MR complex is involved in the processing of DNA double-strand breaks (DSBs), which are among the most harmful forms of DNA damage and their ...

The Molecular Mechanisms of the Mre11/Rad50 DNA Repair Complex

The catalytic mechanism of ATP hydrolysis by Rad50 was determined and several important structural features of the MR complex were identified, ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

Through interacting with other important players of DNA damage response, MRE11-RAD50-NBS1 complex is engaged in various DNA damage repair ...

Turning the Mre11/Rad50 DNA repair complex on its head

In contrast, a second higher fidelity mechanism, homology-directed repair (HDR), requires a homologous chromosome as a template to restore the genetic content ...

The Mre11:Rad50 structure shows an ATP dependent molecular ...

The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to ...

Mre11-Rad50 oligomerization promotes DNA double-strand break ...

known that Mre11-Rad50 foci formation at DNA lesions accompanies repair, the underlying molecular assembly mechanisms and functional ...

Modes of action of the archaeal Mre11/Rad50 DNA-repair complex ...

The Mre11/Rad50 (M/R) DNA-repair complex is an essential molecular machine critical for cellular viability and chromosomal maintenance and is conserved in all ...

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the ...

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at ...

The Molecular Mechanism of Bacteriophage T4 Rad50/Mre11 DNA ...

In eukaryotes, archaea, and some bacteriophage, a complex made up of Mre11 and Rad50, which are a nuclease and ATPase, respectively, is involved ...

Mechanism of DNA End Sensing and Processing by the Mre11 ...

To initiate DSB repair by end joining or homologous recombination, the Mre11-nuclease Rad50-ATPase complex detects and processes diverse and ...

Mechanism of DNA End Sensing and Processing by the Mre11 ...

To initiate DSB repair by end joining or homologous recombination, the Mre11-nuclease. Rad50-ATPase complex detects and processes diverse and ...

The molecular mechanisms of the bacteriophage T4-Mre11/Rad50 ...

DNA double strand breaks (DSBs) are the most harmful type of DNA lesions. The Mre11/Rad50 (MR) protein complex participates in DSB repair and DNA replication.

Mre11–Rad50: the DNA end game | Biochemical Society Transactions

The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of ...

Structure of the Rad50 DNA double‐strand break repair protein in ...

Mre11–Rad50's mechanism in the processing, tethering, and signaling of DSBs is unclear, in part because we lack a structural framework for its interaction with ...

Structural Biochemistry and Interaction Architecture of the DNA ...

To clarify functions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair, we report Pyrococcus furiosus Mre11 crystal structures, ...

Dynamic Properties of the DNA Damage Response Mre11/Rad50 ...

One of the key players for early DNA damage response is the conserved Mre11/Rad50 Nbs1/Xrs2 (MRN/X) complex, which is quickly recruited to the ...

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair ...

To organize the MRN complex, the Mre11 exonuclease directly binds Nbs1, DNA, and Rad50. Rad50, a structural maintenance of chromosome (SMC) related protein, ...

LRET-derived HADDOCK structural models describe the ... - eLife

Mre11-Rad50-Nbs1 (MRN) is an essential protein complex required for the repair of DNA double-strand breaks (DSBs) (Paull, 2018; Syed and Tainer, ...

Molecular Mechanisms of a Highly Conserved DNA Repair Complex ...

A well-conserved protein complex, Mre11/Rad50 (MR), plays a primary role in the initial steps of DNA double-strand break repair. Relatively little is known ...

The Molecular Mechanisms of the Bacteriophage T4-Mre11/Rad50 ...

DNA double strand breaks (DSBs) are the most harmful type of DNA lesions. The Mre11/Rad50 (MR) protein complex participates in DSB repair and DNA replication.