The multifaceted functions of long non|coding RNA HOTAIR in ...

The multifaceted functions of long non-coding RNA HOTAIR in ...

Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal ...

The multifaceted functions of long non-coding RNA HOTAIR in ...

Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology.

overview-of-the-multifaceted-functions-of-lncrna-hotair--in ...

long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma ...

Overview of the Multifaceted Functions of LncRNA HOTAIR in ...

Non-coding RNAs are novel regulatory RNAs that play key roles in different physiological processes such as gene regulation, cell differentiation ...

Scaffold function of long non-coding RNA HOTAIR in protein ...

Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis.

The functional role of long non-coding RNA in human carcinomas

One of the first lncRNAs described to have a fundamental role in cancer was the metastasis-associated HOX Antisense Intergenic RNA (HOTAIR), a ...

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS ...

Introduction. Long non-coding RNAs (lncRNAs) are RNA species with sizes greater than 200 nucleotides that are not translated into polypeptides.

The multifaceted roles of long noncoding RNAs in pancreatic cancer

HOTAIR is the most well-characterized lncRNA in cancers [49]. HOTAIR is transcribed from the human HOXC locus on chromosome 12 and interacts ...

Functions and underlying mechanisms of lncRNA HOTAIR in cancer ...

In recent years, many studies have shown that homeobox transcript antisense intergenic RNA (HOTAIR) is involved in many pathological processes ...

Long Non-coding RNA HOTAIR Function as a Competing ... - Frontiers

LncRNA HOTAIR and HNRNPA1 are reported to play an oncogenic role in non-small cell lung cancer, and the overexpression of HNRNPA1 is shown to ...

HOTAIR: an oncogenic long non-coding RNA in different cancers

HOTAIR is an lncRNA that plays a role as an oncogenic molecule in different cancer cells, such as breast, gastric, colorectal, and cervical cancer cells.

Long non-coding RNAs: Mechanism of action and functional utility

HOTAIR and other lncRNAs function as scaffolds (Fig. 1B) coordinate the targeting of specific repressive histone modifying complexes to target loci [26] ...

The Long Noncoding RNA HOTAIR in Breast Cancer - MDPI

HOTAIR (HOX transcript antisense RNA) plays a critical role in chromatin dynamics through the interaction with histone modifiers resulting ...

The multifaceted functions of long non-coding RNA HOTAIR in ...

The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget. Ahmad F 1 ...

(PDF) Roles of HOTAIR Long Non-coding RNA in Gliomas and ...

HOTAIR also binds to and competitively inhibits the functions of target miRNAs, altering the expression of downstream genes.

The role of HOTAIR in the modulation of resistance to anticancer ...

Among these, the lncRNA homeobox transcript antisense intergenic RNA (HOTAIR), widely implicated in cancer initiation and progression, likewise plays a ...

The long non-coding RNA HOTAIR enhances pancreatic cancer ...

However, the role of HOTAIR in pancreatic cancer resistance to anticancer agents is unknown. The present study determined the role of HOTAIR in pancreatic ...

[PDF] Scaffold function of long non-coding RNA HOTAIR in protein ...

It is shown that HOTAIR serves as a scaffold between E3 ubiquitin ligases and their substrates and thereby enhances their ubiquitination, and uncover a role ...

Roles of HOTAIR Long Non-coding RNA in Gliomas and Other CNS ...

... non-coding RNAs in cancer chemoresistance: unravelling the multifaceted role and prospective therapeutic targeting. Mol Biol Rep 47:5569–5585. https://doi ...

history, present, and future of long non-coding RNAs in cancer

The binding of lncRNAs to RBPs can alter the function of these proteins, influencing mRNA stability and translation, RNA splicing, and other ...